MolNFT v1 · #500547 · protein
AlphaFold monomer V2.0 prediction for NEDD4-like E3 ubiquitin-protein ligase WWP2 (O00308)
O00308: “AlphaFold monomer V2.0 prediction for NEDD4-like E3 ubiquitin-protein ligase WWP2 (O00308)”. 12 pockets (best druggability 0.73). MolNFT v1 #500547 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- O00308
- Type
- protein
- Length
- 870 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x76FE725d33d5838c54501068f07a12aAb661539b
- Molecule
- NEDD4-like E3 ubiquitin-protein ligase WWP2
- UniProt
- O00308
- Pockets
- 12 · best druggability 0.73
Structure
1 distinct chain · 26% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | NEDD4-like E3 ubiquitin-protein ligase WWP2 | protein | 870 | 26% helix, 22% strand | O00308 |
Pockets
12 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 485 | 0.73 | 0.82 | 40 | empty |
| 2 | 396 | 0.71 | 0.83 | 50 | empty |
| 3 | 346 | 0.67 | 0.81 | 51 | empty |
| 4 | 132 | 0.57 | 0.83 | 26 | empty |
| 5 | 272 | 0.55 | 0.76 | 37 | empty |
Compared structures
- 5TJ7 · Structure of WWP2 WW2-2,3-linker-hect aa 334-398 linked to 485-865 · an experimental structure of the same protein · chain A against B, TM-score 0.50
- 5TJ8 · Structure of WWP2 WW2-2,3-linker-hect (no WW2 observed) · an experimental structure of the same protein · chain A against A, TM-score 0.46
- 6J1Z · WWP2 semi-open conformation · an experimental structure of the same protein · chain A against A, TM-score 0.45
- 6J1Z · WWP2 semi-open conformation · an experimental structure of the same protein · chain A against A, TM-score 0.45
- 5TJQ · Structure of WWP2 2,3-linker-hect · an experimental structure of the same protein · chain A against A, TM-score 0.41
- 4Y07 · Crystal structure of the hect domain of human WWP2 · an experimental structure of the same protein · chain A against A, TM-score 0.38
- 4Y07 · Crystal structure of the HECT domain of human WWP2 · an experimental structure of the same protein · chain A against A, TM-score 0.38
- 6RSS · Solution structure of the fourth ww domain of WWP2 with GB1-tag · an experimental structure of the same protein · chain A against A, TM-score 0.07
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O00308
- Elsewhere: UniProt O00308 · AlphaFold DB O00308
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