MolNFT v1 · #134918 · protein
Structure of WWP2 WW2-2,3-linker-hect (no WW2 observed)
5TJ8 · NEDD4-like E3 ubiquitin-protein ligase WWP2,NEDD4-like E3…: “Structure of WWP2 WW2-2,3-linker-hect (no WW2 observed)”. X-ray diffraction, 1 ligand (NA), 5 pockets (best druggability 0.78). MolNFT v1 #134918 on GenesisL1: 3D…
- PDB
- 5TJ8
- Type
- protein
- Length
- 408 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- NEDD4-like E3 ubiquitin-protein ligase WWP2,NEDD4-like E3 ubiquitin-protein ligase WWP2
- EC
- 2.3.2.26
- UniProt
- O00308
- Ligands
- NA
- Pockets
- 5 · best druggability 0.78
Structure
x-ray diffraction · 1 distinct chain · 50% helix, 11% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | NEDD4-like E3 ubiquitin-protein ligase WWP2,NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 2.3.2.26) | protein | 408 | 50% helix, 11% strand | O00308 |
Ligands and binding sites
- NA · Sodium ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 614 | 0.78 | 0.83 | 63 | empty |
| 2 | 154 | 0.73 | 0.91 | 22 | empty |
| 3 | 133 | 0.56 | 0.82 | 23 | empty |
| 4 | 66 | 0.38 | 0.79 | 14 | empty |
| 5 | 65 | 0.31 | 0.75 | 16 | empty |
Compared structures
- 5TJ8 · Structure of WWP2 WW2-2,3-linker-HECT (no WW2 observed) · the same entry in another collection · chain A against A, TM-score 1.00
- O00308 · AlphaFold monomer V2.0 prediction for NEDD4-like E3 ubiquitin-protein ligase WWP2 (O00308) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O00308
- Elsewhere: RCSB PDB 5TJ8 · PDBe 5TJ8 · UniProt O00308
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