UniProt O00308
NEDD4-like E3 ubiquitin-protein ligase WWP2 (O00308)
NEDD4-like E3 ubiquitin-protein ligase WWP2 (UniProt O00308), EC 2.3.2.26: 16 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 85 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- O00308
- Protein
- NEDD4-like E3 ubiquitin-protein ligase WWP2
- EC
- 2.3.2.26
- Experimental structures
- 16
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 85 · 9 records with a druggable one
Structures
17 records of O00308 in the MolNFT archive: 16 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4Y07 | Crystal structure of the HECT domain of human WWP2 | x-ray diffraction | A | — | — |
| 4Y07 | Crystal structure of the hect domain of human WWP2 | x-ray diffraction | A | — | — |
| 5TJ7 | Structure of WWP2 WW2-2,3-linker-HECT aa 334-398 linked to 485-865 | x-ray diffraction | A, B, C, D | NA, SCN, CL | 20 (best 0.88) |
| 5TJ7 | Structure of WWP2 WW2-2,3-linker-hect aa 334-398 linked to 485-865 | x-ray diffraction | A, B, C, D | NA, SCN, CL | — |
| 5TJ8 | Structure of WWP2 WW2-2,3-linker-HECT (no WW2 observed) | x-ray diffraction | A | NA | 5 (best 0.78) |
| 5TJ8 | Structure of WWP2 WW2-2,3-linker-hect (no WW2 observed) | x-ray diffraction | A | NA | — |
| 5TJQ | Structure of WWP2 2,3-linker-HECT | x-ray diffraction | A | — | 2 (best 0.74) |
| 5TJQ | Structure of WWP2 2,3-linker-hect | x-ray diffraction | A | — | — |
| 6J1Z | WWP2 semi-open conformation | x-ray diffraction | A | — | — |
| 6J1Z | WWP2 semi-open conformation | x-ray diffraction | A | — | — |
| 6RSS | Solution structure of the fourth ww domain of WWP2 with GB1-tag | solution nmr | A | — | — |
| 8EI5 | Crystal structure of the WWP2 HECT domain in complex with H301, a Helicon Polypeptide | x-ray diffraction | A, B, C, D | ZN, WHL | 20 (best 0.75) |
| 8EI6 | Crystal structure of the WWP2 HECT domain in complex with H305, a Helicon Polypeptide | x-ray diffraction | A, B | — | 10 (best 0.71) |
| 8EI7 | Crystal structure of the WWP2 HECT domain in complex with H304, a Helicon Polypeptide | x-ray diffraction | A, B | ZN, WHL | 8 (best 0.76) |
| 8EI8 | Crystal structure of the WWP2 HECT domain in complex with H308, a Helicon Polypeptide | x-ray diffraction | A | WHL | 3 (best 0.73) |
| 9EQH | WWP2 WW2-2,3-linker-HECT (WWP2-LH) | x-ray diffraction | A | NA | 5 (best 0.79) |
| O00308 | AlphaFold monomer V2.0 prediction for NEDD4-like E3 ubiquitin-protein ligase WWP2 (O00308) | predicted | A | — | 12 (best 0.73) |
Ligands
Experiment against prediction
- 8EI8 chain A against the predicted model O00308: TM-score 0.99, RMSD 0.76 Å
- 8EI5 chain C against the predicted model O00308: TM-score 0.99, RMSD 0.77 Å
- 4Y07 chain A against the predicted model O00308: TM-score 0.99, RMSD 0.76 Å
- 4Y07 chain A against the predicted model O00308: TM-score 0.99, RMSD 0.76 Å
- 8EI5 chain D against the predicted model O00308: TM-score 0.99, RMSD 0.90 Å
- 8EI5 chain A against the predicted model O00308: TM-score 0.98, RMSD 0.96 Å
- 8EI7 chain A against the predicted model O00308: TM-score 0.98, RMSD 1.03 Å
- 5TJQ chain A against the predicted model O00308: TM-score 0.98, RMSD 0.93 Å
- 5TJQ chain A against the predicted model O00308: TM-score 0.98, RMSD 0.93 Å
- 8EI5 chain B against the predicted model O00308: TM-score 0.98, RMSD 1.00 Å
Elsewhere
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