MolNFT v1 · #487189 · protein
AlphaFold monomer V2.0 prediction for ubiquitin carboxyl-terminal hydrolase 8 (P50102)
P50102: “AlphaFold monomer V2.0 prediction for ubiquitin carboxyl-terminal hydrolase 8 (P50102)”. 4 pockets (best druggability 0.42). MolNFT v1 #487189 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- P50102
- Type
- protein
- Length
- 471 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x71112d4fF7ebb3b617963c05f052289e073082FD
- Molecule
- Ubiquitin carboxyl-terminal hydrolase 8
- UniProt
- P50102
- Pockets
- 4 · best druggability 0.42
Structure
1 distinct chain · 34% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ubiquitin carboxyl-terminal hydrolase 8 | protein | 471 | 34% helix, 25% strand | P50102 |
Pockets
4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 58 | 0.42 | 0.82 | 19 | empty |
| 2 | 96 | 0.36 | 0.74 | 15 | empty |
| 3 | 67 | 0.28 | 0.73 | 16 | empty |
| 4 | 56 | 0.27 | 0.73 | 13 | empty |
Compared structures
- 3MHS · Structure of the saga UBP8/SGF11/SUS1/SGF73 dub module bound to ubiquitin aldehyde · an experimental structure of the same protein · chain A against A, TM-score 0.96
- 3MHS · Structure of the SAGA Ubp8/Sgf11/Sus1/Sgf73 DUB module bound to ubiquitin aldehyde · an experimental structure of the same protein · chain A against A, TM-score 0.96
- 4ZUX · Saga dub module UBP8/SGF11/SUS1/SGF73 bound to ubiqitinated nucleosome · an experimental structure of the same protein · chain A against e, TM-score 0.95
- 6AQR · SAGA DUB module Ubp8(C146A)/Sgf11/Sus1/Sgf73 bound to monoubiquitin · an experimental structure of the same protein · chain A against A, TM-score 0.93
- 6AQR · Saga dub module UBP8(C146A)/SGF11/SUS1/SGF73 bound to monoubiquitin · an experimental structure of the same protein · chain A against A, TM-score 0.93
- 6T9L · SAGA DUB module bound to a ubiqitinated nucleosome · an experimental structure of the same protein · chain A against K, TM-score 0.93
- 6T9L · Saga dub module bound to a ubiqitinated nucleosome · an experimental structure of the same protein · chain A against K, TM-score 0.93
- 4WA6 · Structure of yeast saga dubm with SGF73 N59D mutant at 2.36 ångströms resolution · an experimental structure of the same protein · chain A against A, TM-score 0.90
- 4WA6 · Structure of yeast SAGA DUBm with Sgf73 N59D mutant at 2.36 angstroms resolution · an experimental structure of the same protein · chain A against A, TM-score 0.90
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P50102
- Elsewhere: UniProt P50102 · AlphaFold DB P50102
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