MolNFT v1 · #436548 · protein
AlphaFold monomer V2.0 prediction for slit-robo rho GTPase-activating protein 2 (O75044)
O75044: “AlphaFold monomer V2.0 prediction for slit-robo rho GTPase-activating protein 2 (O75044)”. 7 pockets (best druggability 0.50). MolNFT v1 #436548 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- O75044
- Type
- protein
- Length
- 1,071 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xE98bd0722a8eEb0377b675F85e9ceBC2DbC988D6
- Molecule
- Slit-robo rho GTPase-activating protein 2
- UniProt
- O75044
- Pockets
- 7 · best druggability 0.50
Structure
1 distinct chain · 52% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Slit-robo rho GTPase-activating protein 2 | protein | 1071 | 52% helix, 3% strand | O75044 |
Pockets
7 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 66 | 0.50 | 0.85 | 19 | empty |
| 2 | 176 | 0.48 | 0.76 | 36 | empty |
| 3 | 103 | 0.38 | 0.75 | 19 | empty |
| 4 | 59 | 0.35 | 0.78 | 15 | empty |
| 5 | 88 | 0.33 | 0.73 | 21 | empty |
Compared structures
- 5I6R · Crystal Structure of srGAP2 F-BARx WT Form-1 · an experimental structure of the same protein · chain A against A, TM-score 0.39
- 5I6R · Crystal structure of SRGAP2 F-barx wt form-1 · an experimental structure of the same protein · chain A against A, TM-score 0.39
- 5I6J · Crystal structure of SRGAP2 F-barx · an experimental structure of the same protein · chain A against A, TM-score 0.38
- 5I6J · Crystal Structure of SRGAP2 F-BARx · an experimental structure of the same protein · chain A against A, TM-score 0.38
- 5I7D · Crystal structure of SRGAP2 F-barx wt form-2 · an experimental structure of the same protein · chain A against A, TM-score 0.37
- 5I7D · Crystal Structure of srGAP2 F-BARx WT Form-2 · an experimental structure of the same protein · chain A against A, TM-score 0.37
- 2DL8 · Solution structure of the SH3 domain of human SLIT-ROBO Rho GTPase-activating protein 2 · an experimental structure of the same protein · chain A against A, TM-score 0.06
- 2DL8 · Solution structure of the SH3 domain of human slit-robo rho GTPase- activating protein 2 · an experimental structure of the same protein · chain A against A, TM-score 0.06
- 4RUG · Cyrstal structure of slit-robo rho GTPase-activating protein 2 fragment · an experimental structure of the same protein · chain A against A, TM-score 0.06
- 4RUG · Cyrstal structure of SLIT-ROBO Rho GTPase-activating protein 2 fragment · an experimental structure of the same protein · chain A against A, TM-score 0.06
- 4RTT · Cyrstal structure of slit-robo rho GTPase-activating protein 2 fragment · an experimental structure of the same protein · chain A against B, TM-score 0.06
- 4RTT · Cyrstal structure of SLIT-ROBO Rho GTPase-activating protein 2 fragment · an experimental structure of the same protein · chain A against B, TM-score 0.06
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O75044
- Elsewhere: UniProt O75044 · AlphaFold DB O75044
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