MolNFT v1 · #106255 · protein
Cyrstal structure of slit-robo rho GTPase-activating protein 2 fragment
4RTT: “Cyrstal structure of slit-robo rho GTPase-activating protein 2 fragment”. X-ray diffraction, 1 ligand (SO4), 2 pockets (best druggability 0.30). MolNFT v1 #106255 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4RTT
- Type
- protein
- Length
- 160 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Slit-robo rho GTPase-activating protein 2
- UniProt
- O75044
- Ligands
- SO4
- Pockets
- 2 · best druggability 0.30
Structure
x-ray diffraction · 2 distinct chains · 15% helix, 40% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Slit-robo rho GTPase-activating protein 2 | protein | 80 | 15% helix, 40% strand | O75044 |
| B | Slit-robo rho GTPase-activating protein 2 | protein | 80 | 15% helix, 40% strand | O75044 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 3 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 87 | 0.30 | 0.72 | 14 | empty |
| 2 | 55 | 0.29 | 0.75 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 576 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 4RTT · Cyrstal structure of SLIT-ROBO Rho GTPase-activating protein 2 fragment · the same entry in another collection · chain A against A, TM-score 1.00
- O75044 · AlphaFold monomer V2.0 prediction for slit-robo rho GTPase-activating protein 2 (O75044) · a predicted model of the same protein · chain B against A, TM-score 0.72
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O75044
- Elsewhere: RCSB PDB 4RTT · PDBe 4RTT · UniProt O75044
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