MolNFT v1 · #121844 · protein

Crystal structure of SRGAP2 F-barx wt form-2

5I7D · Slit-robo rho GTPase-activating protein 2: “Crystal structure of SRGAP2 F-barx wt form-2”. X-ray diffraction, 4 pockets (best druggability 0.38). MolNFT v1 #121844 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5I7D
Type: protein
Length: 818 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Slit-robo rho GTPase-activating protein 2
UniProt: O75044
Pockets: 4 · best druggability 0.38

Structure

x-ray diffraction · 1 distinct chain · 82% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Slit-robo rho GTPase-activating protein 2	protein	409	82% helix, 0% strand	O75044

Pockets

4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	63	0.38	0.78	19	empty
2	85	0.37	0.75	14	empty
3	66	0.37	0.78	14	empty
4	86	0.36	0.75	14	empty

Compared structures

5I7D · Crystal Structure of srGAP2 F-BARx WT Form-2 · the same entry in another collection · chain A against A, TM-score 1.00
O75044 · AlphaFold monomer V2.0 prediction for slit-robo rho GTPase-activating protein 2 (O75044) · a predicted model of the same protein · chain A against A, TM-score 0.92

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O75044
Elsewhere: RCSB PDB 5I7D · PDBe 5I7D · UniProt O75044

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