MolNFT v1 · #386882 · protein

AlphaFold monomer V2.0 prediction for DNA-directed RNA polymerase subunit alpha (Q72I32)

Q72I32: “AlphaFold monomer V2.0 prediction for DNA-directed RNA polymerase subunit alpha (Q72I32)”. 2 pockets (best druggability 0.43). MolNFT v1 #386882 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

Accession: Q72I32
Type: protein
Length: 315 residues
Chains: 1
Collection: MolNFT v1 / AlphaFold
Contract: 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
Owner: 0x025f3b1a898b05AD2731bE6Ab72687b5920c4A3F
Molecule: DNA-directed RNA polymerase subunit alpha
UniProt: Q72I32
Pockets: 2 · best druggability 0.43

Structure

1 distinct chain · 31% helix, 31% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	DNA-directed RNA polymerase subunit alpha	protein	315	31% helix, 31% strand	Q72I32

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	84	0.43	0.80	20	empty
2	87	0.42	0.79	14	empty

Compared structures

6CUU · Thermus thermophiles RNA polymerase in complex with promoter DNA and antibiotic… · an experimental structure of the same protein · chain A against A, TM-score 0.70
5VOI · X-ray crystal structure of bacterial RNA polymerase and pyrg promoter complex · an experimental structure of the same protein · chain A against A, TM-score 0.70

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q72I32
Elsewhere: UniProt Q72I32 · AlphaFold DB Q72I32

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