UniProt Q72I32
DNA-directed RNA polymerase subunit alpha (Q72I32)
DNA-directed RNA polymerase subunit alpha (UniProt Q72I32), EC 2.7.7.6: 3 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 8 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q72I32
- Protein
- DNA-directed RNA polymerase subunit alpha
- EC
- 2.7.7.6
- Experimental structures
- 3
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 8 · 1 record with a druggable one
Structures
4 records of Q72I32 in the MolNFT archive: 3 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5VOI | X-ray crystal structure of bacterial RNA polymerase and pyrg promoter complex | x-ray diffraction | A, B | MG | — |
| 6CUU | Thermus thermophiles RNA polymerase in complex with promoter DNA and antibiotic Kanglemycin A | x-ray diffraction | A, B | MG | 6 (best 0.86) |
| 6CUU | Thermus thermophiles RNA polymerase in complex with promoter DNA and antibiotic kanglemycin a | x-ray diffraction | A, B | MG | — |
| Q72I32 | AlphaFold monomer V2.0 prediction for DNA-directed RNA polymerase subunit alpha (Q72I32) | predicted | A | — | 2 (best 0.43) |
Ligands
- MG · Magnesium ion · in 3 records
Experiment against prediction
- 5VOI chain A against the predicted model Q72I32: TM-score 0.97, RMSD 1.14 Å
- 6CUU chain A against the predicted model Q72I32: TM-score 0.97, RMSD 1.23 Å
- 6CUU chain A against the predicted model Q72I32: TM-score 0.97, RMSD 1.23 Å
- 5VOI chain B against the predicted model Q72I32: TM-score 0.93, RMSD 1.66 Å
- 6CUU chain B against the predicted model Q72I32: TM-score 0.92, RMSD 1.69 Å
- 6CUU chain B against the predicted model Q72I32: TM-score 0.92, RMSD 1.69 Å
Elsewhere
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