AlphaFold monomer V2.0 prediction for pre-mRNA-splicing factor 8 (P33334)

Structure

1 distinct chain · 41% helix, 13% strand (DSSP).

Pockets

20 pockets found on a 1 Å grid, 19 with a druggability of 0.5 or more.

Compared structures

• 5LQW · yeast activated spliceosome · an experimental structure of the same protein · chain A against A, TM-score 0.84
• 6J6Q · Cryo-EM structure of the yeast B*-b2 complex at an average resolution of 3.7 angstrom · an experimental structure of the same protein · chain A against A, TM-score 0.69
• 5WSG · Cryo-EM structure of the Catalytic Step II spliceosome (C* complex) at 4.0 angstrom… · an experimental structure of the same protein · chain A against A, TM-score 0.69
• 5YLZ · Cryo-EM Structure of the Post-catalytic Spliceosome from Saccharomyces cerevisiae at 3.6… · an experimental structure of the same protein · chain A against A, TM-score 0.69
• 6EXN · Post-catalytic P complex spliceosome with 3' splice site docked · an experimental structure of the same protein · chain A against A, TM-score 0.69
• 3JCM · Cryo-EM structure of the spliceosomal U4/U6.U5 tri-snRNP · an experimental structure of the same protein · chain A against A, TM-score 0.53
• 3ZEF · Crystal structure of Prp8:Aar2 complex: second crystal form at 3.1 Angstrom resolution · an experimental structure of the same protein · chain A against E, TM-score 0.37
• 4I43 · Crystal structure of Prp8:Aar2 complex · an experimental structure of the same protein · chain A against B, TM-score 0.37
• 5GAM · Foot region of the yeast spliceosomal U4/U6.U5 tri-snRNP · an experimental structure of the same protein · chain A against A, TM-score 0.24
• 3SBG · Crystal structure of a Prp8 C-terminal fragment · an experimental structure of the same protein · chain A against A, TM-score 0.12
• 3E9P · Crystal Structure of Yeast Prp8, Residues 1827-2092 · an experimental structure of the same protein · chain A against A, TM-score 0.10

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P33334
• Elsewhere: UniProt P33334 · AlphaFold DB P33334