AlphaFold monomer V2.0 prediction for pre-mRNA-splicing factor 8 (P33334)

Structure

1 distinct chain · 41% helix, 13% strand (DSSP).

Pockets

20 pockets found on a 1 Å grid, 19 with a druggability of 0.5 or more.

Compared structures

• 5GM6 · Cryo-EM structure of the activated spliceosome (Bact complex) at 3.5 angstrom resolution · an experimental structure of the same protein · chain A against A, TM-score 0.87
• 5LQW · yeast activated spliceosome · an experimental structure of the same protein · chain A against A, TM-score 0.84
• 6J6Q · Cryo-EM structure of the yeast B*-b2 complex at an average resolution of 3.7 angstrom · an experimental structure of the same protein · chain A against A, TM-score 0.69
• 6J6H · Cryo-EM structure of the yeast B*-a1 complex at an average resolution of 3.6 angstrom · an experimental structure of the same protein · chain A against A, TM-score 0.69
• 6J6G · Cryo-EM structure of the yeast B*-a2 complex at an average resolution of 3.2 angstrom · an experimental structure of the same protein · chain A against A, TM-score 0.69
• 6BK8 · S. cerevisiae spliceosomal post-catalytic P complex · an experimental structure of the same protein · chain A against A, TM-score 0.69
• 6J6N · Cryo-EM structure of the yeast B*-b1 complex at an average resolution of 3.86 angstrom · an experimental structure of the same protein · chain A against A, TM-score 0.69
• 5WSG · Cryo-EM structure of the Catalytic Step II spliceosome (C* complex) at 4.0 angstrom… · an experimental structure of the same protein · chain A against A, TM-score 0.69
• 5GMK · Cryo-EM structure of the Catalytic Step I spliceosome (C complex) at 3.4 angstrom… · an experimental structure of the same protein · chain A against A, TM-score 0.69
• 9DTR · Structure of the yeast post-catalytic P complex spliceosome at 2.3 Angstrom resolution · an experimental structure of the same protein · chain A against A, TM-score 0.69
• 5LJ5 · Overall structure of the yeast spliceosome immediately after branching. · an experimental structure of the same protein · chain A against A, TM-score 0.69
• 5YLZ · Cryo-EM Structure of the Post-catalytic Spliceosome from Saccharomyces cerevisiae at 3.6… · an experimental structure of the same protein · chain A against A, TM-score 0.69

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P33334
• Elsewhere: UniProt P33334 · AlphaFold DB P33334