UniProt P33334
Pre-mRNA-splicing factor 8 (P33334)
Pre-mRNA-splicing factor 8 (UniProt P33334): 304 experimental structures and 1 predicted model on GenesisL1, 37 ligands bound, 229 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P33334
- Protein
- Pre-mRNA-splicing factor 8
- Experimental structures
- 304
- Predicted models
- 1
- Ligands
- 37
- Pockets
- 229 · 11 records with a druggable one
Structures
305 records of P33334 in the MolNFT archive: 304 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2OG4 | Structure of an expanded Jab1-MPN-like domain of splicing factor Prp8p from yeast | x-ray diffraction | A | — | — |
| 2OG4 | Structure of an expanded JAB1-mpn-like domain of splicing factor PRP8P from yeast | x-ray diffraction | A | — | — |
| 3E66 | Crystal structure of the beta-finger domain of yeast Prp8 | x-ray diffraction | A, B | — | — |
| 3E66 | Crystal structure of the beta-finger domain of yeast PRP8 | x-ray diffraction | A, B | — | — |
| 3E9O | Crystal Structure of Yeast Prp8, Residues 1836-2092 | x-ray diffraction | A | — | — |
| 3E9O | Crystal structure of yeast PRP8, residues 1836-2092 | x-ray diffraction | A | — | — |
| 3E9P | Crystal Structure of Yeast Prp8, Residues 1827-2092 | x-ray diffraction | A, B | — | — |
| 3E9P | Crystal structure of yeast PRP8, residues 1827-2092 | x-ray diffraction | A, B | — | — |
| 3JCM | Cryo-EM structure of the spliceosomal U4/U6.U5 tri-snRNP | electron microscopy | A | — | — |
| 3JCM | Cryo-EM structure of the spliceosomal U4/U6.U5 tri-snrnp | electron microscopy | A | — | — |
| 3SBG | Crystal structure of a Prp8 C-terminal fragment | x-ray diffraction | A | — | — |
| 3SBG | Crystal structure of a PRP8 C-terminal fragment | x-ray diffraction | A | — | — |
| 3SBT | Crystal structure of a Aar2-Prp8 complex | x-ray diffraction | A | — | — |
| 3SBT | Crystal structure of a AAR2-PRP8 complex | x-ray diffraction | A | — | — |
| 3ZEF | Crystal structure of Prp8:Aar2 complex: second crystal form at 3.1 Angstrom resolution | x-ray diffraction | B, E | — | — |
| 3ZEF | Crystal structure of PRP8:AAR2 complex: second crystal form at 3.1 ångström resolution | x-ray diffraction | B, E | — | — |
| 4BGD | Crystal structure of Brr2 in complex with the Jab1/MPN domain of Prp8 | x-ray diffraction | C | — | — |
| 4BGD | Crystal structure of BRR2 in complex with the JAB1/MPN domain of PRP8 | x-ray diffraction | C | — | — |
| 4I43 | Crystal structure of Prp8:Aar2 complex | x-ray diffraction | B | — | — |
| 4I43 | Crystal structure of PRP8:AAR2 complex | x-ray diffraction | B | — | — |
| 4ILG | Crystal structure of Aar2p in complex with the Prp8p RNaseH and Jab1/MPN domains | x-ray diffraction | B, C | — | — |
| 4ILG | Crystal structure of AAR2P in complex with the PRP8P rnaseh and JAB1/MPN domains | x-ray diffraction | B, C | — | — |
| 4ILH | Crystal structure of an Aar2p C-terminal deletion mutant in conplex with Prp8p RNaseH | x-ray diffraction | A | — | — |
| 4ILH | Crystal structure of an AAR2P C-terminal deletion mutant in conplex with PRP8P rnaseh | x-ray diffraction | A | — | — |
| 4ILJ | Crystal structure of an Prp8p RNaseH W1911A mutant protein | x-ray diffraction | A, B | — | — |
| 4ILJ | Crystal structure of an PRP8P rnaseh W1911A mutant protein | x-ray diffraction | A, B | — | — |
| 5DCA | Crystal structure of yeast full length BRR2 in complex with PRP8 JAB1 domain | x-ray diffraction | J | — | — |
| 5GAM | Foot region of the yeast spliceosomal U4/U6.U5 tri-snRNP | electron microscopy | A | GTP | — |
| 5GAM | Foot region of the yeast spliceosomal U4/U6.U5 tri-snrnp | electron microscopy | A | — | — |
| 5GAN | The overall structure of the yeast spliceosomal U4/U6.U5 tri-snrnp at 3.7 ångström | electron microscopy | A | — | — |
| 5GAO | Head region of the yeast spliceosomal U4/U6.U5 tri-snrnp | electron microscopy | A | — | — |
| 5GAP | Body region of the U4/U6.U5 tri-snrnp | electron microscopy | A | — | — |
| 5GMK | Cryo-EM structure of the catalytic step I spliceosome (C complex) at 3.4 ångström resolution | electron microscopy | A | — | — |
| 5LJ3 | Structure of the core of the yeast spliceosome immediately after branching | electron microscopy | A | — | — |
| 5LJ5 | Overall structure of the yeast spliceosome immediately after branching. | electron microscopy | A | — | — |
| 5LQW | yeast activated spliceosome | electron microscopy | A | — | — |
| 5LQW | Yeast activated spliceosome | electron microscopy | A | — | — |
| 5M52 | Crystal structure of yeast BRR2 full-lenght in complex with PRP8 JAB1 domain | x-ray diffraction | C, D | — | — |
| 5M5P | S. cerevisiae spliceosomal helicase Brr2 (271-end) in complex with the Jab/MPN domain of S.… | x-ray diffraction | B, D | — | — |
| 5M5P | S. cerevisiae spliceosomal helicase BRR2 (271-end) in complex with the JAB/MPN domain of S.… | x-ray diffraction | B, D | — | — |
| 5MPS | Structure of a spliceosome remodeled for exon ligation | electron microscopy | A | IHP, GTP | — |
| 5MQ0 | Structure of a spliceosome remodeled for exon ligation | electron microscopy | A | MG, IHP, GTP | 17 (best 0.88) |
| 5MQ0 | Structure of a spliceosome remodeled for exon ligation | electron microscopy | A | IHP, GTP | — |
| 5QY1 | Pandda analysis group deposition -- AAR2/RNASEH in complex with fragment F2X-entry A07A | x-ray diffraction | A | SO4 | — |
| 5QY2 | Pandda analysis group deposition -- AAR2/RNASEH in complex with fragment F2X-entry A12B | x-ray diffraction | A | SO4 | — |
| 5QY3 | Pandda analysis group deposition -- AAR2/RNASEH in complex with fragment F2X-entry B03A | x-ray diffraction | A | SO4 | — |
| 5QY4 | PanDDA analysis group deposition -- Aar2/RNaseH in complex with fragment F2X-Entry B08a | x-ray diffraction | A | T9S, SO4 | 2 (best 0.56) |
| 5QY4 | Pandda analysis group deposition -- AAR2/RNASEH in complex with fragment F2X-entry B08A | x-ray diffraction | A | T9S, SO4 | — |
| 5QY5 | Pandda analysis group deposition -- AAR2/RNASEH in complex with fragment F2X-entry C02A | x-ray diffraction | A | SO4 | — |
| 5QY6 | Pandda analysis group deposition -- AAR2/RNASEH in complex with fragment F2X-entry C05A | x-ray diffraction | A | SY7, SO4 | — |
| 5QY7 | Pandda analysis group deposition -- AAR2/RNASEH in complex with fragment F2X-entry C08A | x-ray diffraction | A | SO4 | — |
| 5QY8 | PanDDA analysis group deposition -- Aar2/RNaseH in complex with fragment F2X-Entry C10a | x-ray diffraction | A | TJV, SO4 | — |
| 5QY8 | Pandda analysis group deposition -- AAR2/RNASEH in complex with fragment F2X-entry C10A | x-ray diffraction | A | TJV, SO4 | — |
| 5QY9 | PanDDA analysis group deposition -- Aar2/RNaseH in complex with fragment F2X-Entry C11b | x-ray diffraction | A | R8Y, SO4 | — |
| 5QY9 | Pandda analysis group deposition -- AAR2/RNASEH in complex with fragment F2X-entry C11B | x-ray diffraction | A | R8Y, SO4 | — |
| 5QYA | Pandda analysis group deposition -- AAR2/RNASEH in complex with fragment F2X-entry D02A | x-ray diffraction | A | SY4, SO4 | — |
| 5QYB | PanDDA analysis group deposition -- Aar2/RNaseH in complex with fragment F2X-Entry D06a | x-ray diffraction | A | R9G, SO4 | 3 (best 0.37) |
| 5QYB | Pandda analysis group deposition -- AAR2/RNASEH in complex with fragment F2X-entry D06A | x-ray diffraction | A | R9G, SO4 | — |
| 5QYC | Pandda analysis group deposition -- AAR2/RNASEH in complex with fragment F2X-entry D07A | x-ray diffraction | A | SYJ, SO4 | — |
| 5QYD | Pandda analysis group deposition -- AAR2/RNASEH in complex with fragment F2X-entry E05A | x-ray diffraction | A | R9S, SO4 | — |
245 records more on the page itself.
Ligands
- SO4 · Sulfate ion · in 25 records
- GTP · Guanosine-5'-triphosphate · in 19 records
- IHP · Inositol hexakisphosphate · in 17 records
- MG · Magnesium ion · in 6 records
- R8Y · N-ethyl-N-(thiophene-2-carbonyl)-beta-alanine · in 4 records
- R9G · (3-methoxyphenyl)(pyrrolidin-1-yl)methanone · in 3 records
- R9S · 2-(2-methylphenyl)acetamide · in 3 records
- RBJ · 4-[(methylamino)methyl]phenol · in 3 records
- SY7 · 2-methoxy-4-[[(4~{S},5~{S})-2,4,5-tris(2-methoxypyridin-4-yl)imidazolidin-1-yl]methyl]pyridine · in 3 records
- SY4 · ~{N}-[5-azanyl-2,4-bis(fluoranyl)phenyl]propane-1-sulfonamide · in 2 records
- SYJ · 2-fluoranyl-~{N}-(furan-2-ylmethyl)benzenesulfonamide · in 2 records
- SYV · 6-azanyl-3-methyl-1,3-benzoxazol-2-one · in 2 records
- T9S · ethyl 1,3-dihydro-2H-pyrrolo[3,4-c]pyridine-2-carboxylate · in 2 records
- TBJ · N-cyclopentyl-N'-{[(2R)-oxolan-2-yl]methyl}urea · in 2 records
- TJV · 1,3-benzodioxole-5-carbothioamide · in 2 records
- KGN · D-chiro inositol hexakisphosphate · in 1 record
- SZA · ~{N}-(2-thiophen-2-ylethyl)pyridine-4-carboxamide · in 1 record
- T9V · N-(4-methoxyphenyl)acetamide · in 1 record
- USP · (2R)-6-amino-3-methyl-2,3-dihydro-1,3-benzoxazol-2-ol · in 1 record
- UWI · oxane-4-carboxamide · in 1 record
- V2U · 2-chloro-N-(3,5-dimethoxyphenyl)acetamide · in 1 record
- V6Z · methyl N-(2-chlorobenzoyl)glycinate · in 1 record
- VBI · N~2~-(3-chlorophenyl)-N~2~-(methanesulfonyl)-N-methylglycinamide · in 1 record
- VDD · (2S)-2-[(pyridin-2-yl)sulfanyl]propanoic acid · in 1 record
- VJI · (1R)-1-(2,3-dihydro-1,4-benzodioxin-6-yl)ethane-1,2-diamine · in 1 record
- VQ2 · [4-(diethylcarbamoyl)phenyl]boronic acid · in 1 record
- VR6 · N-[(furan-2-yl)methyl]-2-[(pyridin-2-yl)oxy]ethan-1-amine · in 1 record
- VU9 · 1-phenylpiperazine · in 1 record
- VUU · N-cyclopropyl-N'-[2-(thiophen-2-yl)ethyl]guanidine · in 1 record
- VV0 · 4-amino-3-methyl-N-(propan-2-yl)benzamide · in 1 record
Experiment against prediction
- 4BGD chain C against the predicted model P33334: TM-score 0.98, RMSD 0.84 Å
- 5M5P chain B against the predicted model P33334: TM-score 0.97, RMSD 1.03 Å
- 4ILG chain C against the predicted model P33334: TM-score 0.97, RMSD 1.17 Å
- 7FO5 chain A against the predicted model P33334: TM-score 0.97, RMSD 1.15 Å
- 7FN1 chain A against the predicted model P33334: TM-score 0.97, RMSD 1.16 Å
- 5QYG chain A against the predicted model P33334: TM-score 0.97, RMSD 1.18 Å
- 5R0I chain A against the predicted model P33334: TM-score 0.97, RMSD 1.18 Å
- 5R0B chain A against the predicted model P33334: TM-score 0.97, RMSD 1.18 Å
- 5R1A chain A against the predicted model P33334: TM-score 0.97, RMSD 1.18 Å
- 5R0H chain A against the predicted model P33334: TM-score 0.97, RMSD 1.19 Å
Elsewhere
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