MolNFT v1 · #267747 · protein
AlphaFold monomer V2.0 prediction for neurogenic locus notch homolog protein 1 (Q01705)
Q01705: “AlphaFold monomer V2.0 prediction for neurogenic locus notch homolog protein 1 (Q01705)”. 14 pockets (best druggability 0.74). MolNFT v1 #267747 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- Q01705
- Type
- protein
- Length
- 2,531 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x46EfCa788d03A3e879DAcDb96552AB8Bbc7e20b3
- Molecule
- Neurogenic locus notch homolog protein 1
- UniProt
- Q01705
- Pockets
- 14 · best druggability 0.74
Structure
1 distinct chain · 13% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Neurogenic locus notch homolog protein 1 | protein | 2531 | 13% helix, 19% strand | Q01705 |
Pockets
14 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 757 | 0.74 | 0.79 | 99 | empty |
| 2 | 288 | 0.58 | 0.77 | 44 | empty |
| 3 | 301 | 0.57 | 0.77 | 30 | empty |
| 4 | 221 | 0.55 | 0.78 | 31 | empty |
| 5 | 253 | 0.53 | 0.76 | 34 | empty |
Modifications
Observed in the structure: 111 disulfide (disulfide).
Compared structures
- 7ABV · Structure of the S1-cleaved mouse Notch1 Negative Regulatory Region (NRR) · an experimental structure of the same protein · chain A against A, TM-score 0.09
- 7ABV · Structure of the S1-cleaved mouse NOTCH1 negative regulatory region (nrr) · an experimental structure of the same protein · chain A against A, TM-score 0.09
- 5KY8 · mouse POFUT1 in complex with O-glucosylated mouse Notch1 EGF12 mutant (D464G) and GDP · an experimental structure of the same protein · chain A against B, TM-score 0.02
- 5KY8 · Mouse POFUT1 in complex with O-glucosylated mouse NOTCH1 EGF12 mutant (D464G) and GDP · an experimental structure of the same protein · chain A against B, TM-score 0.02
- 5KY0 · Mouse POFUT1 in complex with mouse NOTCH1 EGF12(D464G) and GDP · an experimental structure of the same protein · chain A against B, TM-score 0.01
- 5KY0 · mouse POFUT1 in complex with mouse Notch1 EGF12(D464G) and GDP · an experimental structure of the same protein · chain A against B, TM-score 0.01
- 2RQZ · Structure of sugar modified epidermal growth factor-like repeat 12 of mouse Notch-1… · an experimental structure of the same protein · chain A against A, TM-score 0.01
- 2RQZ · Structure of sugar modified epidermal growth factor-like repeat 12 of mouse notch-1… · an experimental structure of the same protein · chain A against A, TM-score 0.01
- 2RR2 · Structure of O-fucosylated epidermal growth factor-like repeat 12 of mouse notch-1… · an experimental structure of the same protein · chain A against A, TM-score 0.01
- 2RR2 · Structure of O-fucosylated epidermal growth factor-like repeat 12 of mouse Notch-1… · an experimental structure of the same protein · chain A against A, TM-score 0.01
- 5KY4 · mouse POFUT1 in complex with mouse Notch1 EGF26 and GDP · an experimental structure of the same protein · chain A against B, TM-score 0.01
- 5KY4 · Mouse POFUT1 in complex with mouse NOTCH1 EGF26 and GDP · an experimental structure of the same protein · chain A against B, TM-score 0.01
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q01705
- Elsewhere: UniProt Q01705 · AlphaFold DB Q01705
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