UniProt Q01705
Neurogenic locus notch homolog protein 1 (Q01705)
Neurogenic locus notch homolog protein 1 (UniProt Q01705): 13 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 14 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- Q01705
- Protein
- Neurogenic locus notch homolog protein 1
- Experimental structures
- 13
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 14 · 1 record with a druggable one
Structures
14 records of Q01705 in the MolNFT archive: 13 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2RQZ | Structure of sugar modified epidermal growth factor-like repeat 12 of mouse Notch-1 receptor | solution nmr | A | — | — |
| 2RQZ | Structure of sugar modified epidermal growth factor-like repeat 12 of mouse notch-1 receptor | solution nmr | A | — | — |
| 2RR0 | Structure of epidermal growth factor-like repeat 12 of mouse Notch-1 receptor | solution nmr | A | — | — |
| 2RR0 | Structure of epidermal growth factor-like repeat 12 of mouse notch-1 receptor | solution nmr | A | — | — |
| 2RR2 | Structure of O-fucosylated epidermal growth factor-like repeat 12 of mouse Notch-1 receptor | solution nmr | A | — | — |
| 2RR2 | Structure of O-fucosylated epidermal growth factor-like repeat 12 of mouse notch-1 receptor | solution nmr | A | — | — |
| 5KY0 | Mouse POFUT1 in complex with mouse NOTCH1 EGF12(D464G) and GDP | x-ray diffraction | B | — | — |
| 5KY4 | Mouse POFUT1 in complex with mouse NOTCH1 EGF26 and GDP | x-ray diffraction | B | — | — |
| 5KY8 | mouse POFUT1 in complex with O-glucosylated mouse Notch1 EGF12 mutant (D464G) and GDP | x-ray diffraction | B | BGC | — |
| 5KY8 | Mouse POFUT1 in complex with O-glucosylated mouse NOTCH1 EGF12 mutant (D464G) and GDP | x-ray diffraction | B | BGC | — |
| 5KY9 | mouse POFUT1 in complex with mouse Notch1 EGF12 mutant (D464G/A465G) and GDP | x-ray diffraction | B | — | — |
| 5KY9 | Mouse POFUT1 in complex with mouse NOTCH1 EGF12 mutant (D464G/A465G) and GDP | x-ray diffraction | B | — | — |
| 7ABV | Structure of the S1-cleaved mouse NOTCH1 negative regulatory region (nrr) | x-ray diffraction | A | CA, NAG | — |
| Q01705 | AlphaFold monomer V2.0 prediction for neurogenic locus notch homolog protein 1 (Q01705) | predicted | A | — | 14 (best 0.74) |
Ligands
Experiment against prediction
- 7ABV chain A against the predicted model Q01705: TM-score 0.98, RMSD 0.88 Å
- 5KY4 chain B against the predicted model Q01705: TM-score 0.85, RMSD 1.07 Å
- 5KY9 chain B against the predicted model Q01705: TM-score 0.82, RMSD 0.84 Å
- 5KY9 chain B against the predicted model Q01705: TM-score 0.82, RMSD 0.84 Å
- 5KY0 chain B against the predicted model Q01705: TM-score 0.81, RMSD 1.03 Å
- 5KY8 chain B against the predicted model Q01705: TM-score 0.81, RMSD 1.23 Å
- 5KY8 chain B against the predicted model Q01705: TM-score 0.81, RMSD 1.23 Å
- 2RQZ chain A against the predicted model Q01705: TM-score 0.62, RMSD 1.72 Å
- 2RQZ chain A against the predicted model Q01705: TM-score 0.62, RMSD 1.72 Å
- 2RR2 chain A against the predicted model Q01705: TM-score 0.60, RMSD 2.01 Å
Elsewhere
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