MolNFT v1 · #267278 · protein
AlphaFold monomer V2.0 prediction for 25S rRNA (CYTOSINE(2870)-C(5))-methyltransferase (P40991)
P40991: “AlphaFold monomer V2.0 prediction for 25S rRNA (CYTOSINE(2870)-C(5))-methyltransferase (P40991)”. 5 pockets (best druggability 0.68). MolNFT v1 #267278 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- P40991
- Type
- protein
- Length
- 618 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xBF0D2e107Ce1EcD2C4369B042274201DB719AaAF
- Molecule
- 25S rRNA (CYTOSINE(2870)-C(5))-methyltransferase
- UniProt
- P40991
- Pockets
- 5 · best druggability 0.68
Structure
1 distinct chain · 41% helix, 11% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 25S rRNA (CYTOSINE(2870)-C(5))-methyltransferase | protein | 618 | 41% helix, 11% strand | P40991 |
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 729 | 0.68 | 0.76 | 61 | empty |
| 2 | 255 | 0.65 | 0.82 | 22 | empty |
| 3 | 64 | 0.49 | 0.85 | 16 | empty |
| 4 | 61 | 0.48 | 0.84 | 17 | empty |
| 5 | 52 | 0.26 | 0.73 | 10 | empty |
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 7NAC · State E2 nucleolar 60S ribosomal biogenesis intermediate - Composite model · an experimental structure of the same protein · chain A against q, TM-score 0.57
- 6EM5 · State D architectural model (NSA1-tap flag-YTM1) - visualizing the assembly pathway of… · an experimental structure of the same protein · chain A against q, TM-score 0.50
- 6EM5 · State D architectural model (Nsa1-TAP Flag-Ytm1) - Visualizing the assembly pathway of… · an experimental structure of the same protein · chain A against q, TM-score 0.50
- 6ELZ · State E (TAP-Flag-Ytm1 E80A) - Visualizing the assembly pathway of nucleolar pre-60S… · an experimental structure of the same protein · chain A against q, TM-score 0.50
- 7OHR · Nog1-TAP associated immature ribosomal particle population E from S. cerevisiae · an experimental structure of the same protein · chain A against q, TM-score 0.48
- 7NAF · State E2 nucleolar 60S ribosomal biogenesis intermediate - Spb1-MTD local model · an experimental structure of the same protein · chain A against q, TM-score 0.05
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P40991
- Elsewhere: UniProt P40991 · AlphaFold DB P40991
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