AlphaFold monomer V2.0 prediction for 25S rRNA (CYTOSINE(2870)-C(5))-methyltransferase (P40991)

Structure

1 distinct chain · 41% helix, 11% strand (DSSP).

Pockets

5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

• 8V87 · 60S ribosome biogenesis intermediate (Dbp10 post-catalytic structure - Overall map) · an experimental structure of the same protein · chain A against q, TM-score 0.59
• 8V83 · 60S ribosome biogenesis intermediate (Dbp10 pre-catalytic structure - Overall map) · an experimental structure of the same protein · chain A against q, TM-score 0.57
• 8V84 · 60S ribosome biogenesis intermediate (Dbp10 catalytic structure - Overall map) · an experimental structure of the same protein · chain A against q, TM-score 0.57
• 7R7C · State E2 nucleolar 60S ribosomal biogenesis intermediate - L1 stalk local model · an experimental structure of the same protein · chain A against q, TM-score 0.57
• 7NAC · State E2 nucleolar 60S ribosomal biogenesis intermediate - Composite model · an experimental structure of the same protein · chain A against q, TM-score 0.57
• 7R7A · State E1 nucleolar 60S ribosome biogenesis intermediate - Composite model · an experimental structure of the same protein · chain A against q, TM-score 0.57
• 6EM5 · State D architectural model (NSA1-tap flag-YTM1) - visualizing the assembly pathway of… · an experimental structure of the same protein · chain A against q, TM-score 0.50
• 6EM5 · State D architectural model (Nsa1-TAP Flag-Ytm1) - Visualizing the assembly pathway of… · an experimental structure of the same protein · chain A against q, TM-score 0.50
• 6ELZ · State E (TAP-Flag-Ytm1 E80A) - Visualizing the assembly pathway of nucleolar pre-60S… · an experimental structure of the same protein · chain A against q, TM-score 0.50
• 7OHR · Nog1-TAP associated immature ribosomal particle population E from S. cerevisiae · an experimental structure of the same protein · chain A against q, TM-score 0.48
• 7R6K · State E2 nucleolar 60S ribosomal intermediate - Model for Noc2/Noc3 region · an experimental structure of the same protein · chain A against q, TM-score 0.29
• 7NAF · State E2 nucleolar 60S ribosomal biogenesis intermediate - Spb1-MTD local model · an experimental structure of the same protein · chain A against q, TM-score 0.05

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P40991
• Elsewhere: UniProt P40991 · AlphaFold DB P40991