UniProt P40991
25S rRNA (cytosine(2870)-C(5))-methyltransferase (P40991)
25S rRNA (cytosine(2870)-C(5))-methyltransferase (UniProt P40991), EC 2.1.1.310: 8 experimental structures and 1 predicted model on GenesisL1, 8 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- P40991
- Protein
- 25S rRNA (cytosine(2870)-C(5))-methyltransferase
- EC
- 2.1.1.310
- Experimental structures
- 8
- Predicted models
- 1
- Pockets
- 8 · 3 records with a druggable one
Structures
9 records of P40991 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6ELZ | State E (TAP-Flag-Ytm1 E80A) - Visualizing the assembly pathway of nucleolar pre-60S ribosomes | electron microscopy | q | — | — |
| 6EM5 | State D architectural model (Nsa1-TAP Flag-Ytm1) - Visualizing the assembly pathway of nucleolar… | electron microscopy | q | — | 2 (best 0.75) |
| 6EM5 | State D architectural model (NSA1-tap flag-YTM1) - visualizing the assembly pathway of nucleolar… | electron microscopy | q | — | — |
| 7NAC | State E2 nucleolar 60S ribosomal biogenesis intermediate - Composite model | electron microscopy | q | — | — |
| 7NAF | State E2 nucleolar 60S ribosomal biogenesis intermediate - Spb1-MTD local model | electron microscopy | q | — | — |
| 7OHR | Nog1-TAP associated immature ribosomal particle population E from S. cerevisiae | electron microscopy | q | — | — |
| 8V83 | 60S ribosome biogenesis intermediate (Dbp10 pre-catalytic structure - Overall map) | electron microscopy | q | — | — |
| 8V84 | 60S ribosome biogenesis intermediate (Dbp10 catalytic structure - Overall map) | electron microscopy | q | — | 1 (best 0.83) |
| P40991 | AlphaFold monomer V2.0 prediction for 25S rRNA (CYTOSINE(2870)-C(5))-methyltransferase (P40991) | predicted | A | — | 5 (best 0.68) |
Experiment against prediction
- 8V83 chain q against the predicted model P40991: TM-score 0.99, RMSD 0.83 Å
- 8V84 chain q against the predicted model P40991: TM-score 0.98, RMSD 0.87 Å
- 7NAC chain q against the predicted model P40991: TM-score 0.98, RMSD 0.97 Å
- 6EM5 chain q against the predicted model P40991: TM-score 0.96, RMSD 1.31 Å
- 6EM5 chain q against the predicted model P40991: TM-score 0.96, RMSD 1.31 Å
- 6ELZ chain q against the predicted model P40991: TM-score 0.96, RMSD 1.31 Å
- 7OHR chain q against the predicted model P40991: TM-score 0.95, RMSD 1.60 Å
- 7NAF chain q against the predicted model P40991: TM-score 0.85, RMSD 0.51 Å
Elsewhere
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