MolNFT v1 · #263215 · protein
AlphaFold monomer V2.0 prediction for neuropilin and tolloid-like protein 2 (C6K2K4)
C6K2K4: “AlphaFold monomer V2.0 prediction for neuropilin and tolloid-like protein 2 (C6K2K4)”. 2 pockets (best druggability 0.55). MolNFT v1 #263215 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- C6K2K4
- Type
- protein
- Length
- 525 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x05A042b1250f9bed02e55EeF26666C383876906A
- Molecule
- Neuropilin and tolloid-like protein 2
- UniProt
- C6K2K4
- Pockets
- 2 · best druggability 0.55
Structure
1 distinct chain · 17% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Neuropilin and tolloid-like protein 2 | protein | 525 | 17% helix, 24% strand | C6K2K4 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 151 | 0.55 | 0.80 | 23 | empty |
| 2 | 171 | 0.43 | 0.74 | 28 | empty |
Modifications
Observed in the structure: 7 disulfide (disulfide).
Compared structures
- 7F5A · DNQX-bound GluK2-2xNeto2 complex · an experimental structure of the same protein · chain A against E, TM-score 0.42
- 7F5A · Dnqx-bound GLUK2-2XNETO2 complex · an experimental structure of the same protein · chain A against E, TM-score 0.42
- 7F59 · DNQX-bound GluK2-1xNeto2 complex · an experimental structure of the same protein · chain A against E, TM-score 0.35
- 7F59 · Dnqx-bound GLUK2-1XNETO2 complex · an experimental structure of the same protein · chain A against E, TM-score 0.35
- 7F5B · Lbd-tmd focused reconstruction of dnqx-bound GLUK2-1XNETO2 complex · an experimental structure of the same protein · chain A against E, TM-score 0.29
- 7F5B · LBD-TMD focused reconstruction of DNQX-bound GluK2-1xNeto2 complex · an experimental structure of the same protein · chain A against E, TM-score 0.29
- 7F56 · Dnqx-bound GLUK2-1XNETO2 complex, with asymmetric lbd · an experimental structure of the same protein · chain A against E, TM-score 0.22
- 7F56 · DNQX-bound GluK2-1xNeto2 complex, with asymmetric LBD · an experimental structure of the same protein · chain A against E, TM-score 0.22
- 7F57 · Kainate-bound GluK2-1xNeto2 complex, at the desensitized state · an experimental structure of the same protein · chain A against E, TM-score 0.20
- 7F57 · Kainate-bound GLUK2-1XNETO2 complex, at the desensitized state · an experimental structure of the same protein · chain A against E, TM-score 0.20
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt C6K2K4
- Elsewhere: UniProt C6K2K4 · AlphaFold DB C6K2K4
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