Research workbench
Crystal structure of the TRF2-binding motif of SLX4 in complex with the trfh domain of TRF2
Analyse Crystal structure of the TRF2-binding motif of SLX4 in complex with the trfh… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4M7C
- Type
- protein
- Length
- 419 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Telomeric repeat-binding factor 2; Peptide from structure-specific endonuclease subunit…
- UniProt
- Q15554, Q8IY92
- Pockets
- 6 · best druggability 0.52
Structure
x-ray diffraction · 3 distinct chains · 70% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Telomeric repeat-binding factor 2 | protein | 195 | 71% helix, 0% strand | Q15554 |
| B | Telomeric repeat-binding factor 2 | protein | 198 | 71% helix, 0% strand | Q15554 |
| C, D | Peptide from structure-specific endonuclease subunit SLX4 | protein | 13 | 31% helix, 0% strand | Q8IY92 |
Pockets
6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 180 | 0.52 | 0.78 | 23 | empty |
| 2 | 155 | 0.48 | 0.77 | 21 | empty |
| 3 | 65 | 0.34 | 0.76 | 16 | empty |
| 4 | 108 | 0.34 | 0.72 | 18 | empty |
| 5 | 65 | 0.32 | 0.75 | 16 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1197 Ų buried · 7 hydrogen bonds · protein-protein
- A–C · 702 Ų buried · 12 hydrogen bonds · protein-protein
- B–D · 673 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
- 4M7C · Crystal structure of the TRF2-binding motif of SLX4 in complex with the TRFH domain of… · the same entry in another collection · chain A against A, TM-score 1.00
- Q15554 · AlphaFold monomer V2.0 prediction for telomeric repeat-binding factor 2 (Q15554) · a predicted model of the same protein · chain A against A, TM-score 0.98
- Q8IY92 · AlphaFold monomer V2.0 prediction for structure-specific endonuclease subunit SLX4… · a predicted model of the same protein · chain C against A, TM-score 0.34
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q15554
- Every structure of UniProt Q8IY92
- Elsewhere: RCSB PDB 4M7C · PDBe 4M7C · UniProt Q15554 · UniProt Q8IY92
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