Crystal structure of HSTING(H232) in complex with C[G(2',5')PA(2',5') P]

Structure

x-ray diffraction · 2 distinct chains · 43% helix, 25% strand (DSSP).

Ligands and binding sites

• 1YC · 2-amino-9-[(1R,3R,6R,8R,9R,11S,14R,16R,17R,18R)-16-(6-amino-9H-purin-9-yl)-3,11,17,18-tetrahydroxy-3,11-dioxido-2,4,7,10,12,15-hexaoxa-3,11-diphosphatricyclo[12.2.1.1~6,9~]octadec-8-yl]-1,9-dihydro-6H-purin-6-one · ligand · chains A, B
• PO4 · Phosphate ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Interfaces

1 interface between chains.

• A–B · 1873 Ų buried · 18 hydrogen bonds · protein-protein

Compared structures

• 4LOI · Crystal structure of hSTING(H232) in complex with c[G(2',5')pA(2',5')p] · the same entry in another collection · chain A against A, TM-score 1.00
• Q86WV6 · AlphaFold monomer V2.0 prediction for stimulator of interferon genes protein (Q86WV6) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q86WV6
• Elsewhere: RCSB PDB 4LOI · PDBe 4LOI · UniProt Q86WV6