BRD4 bromodomain 2 in complex with acetylated rel peptide

Structure

x-ray diffraction · 2 distinct chains · 67% helix, 0% strand (DSSP).

Ligands and binding sites

• DTT · 2,3-dihydroxy-1,4-dithiobutane · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

• A–B · 412 Ų buried · 2 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 1 covalent, 1 modified (additive adduct, acetylation).

Compared structures

• 4KV4 · Brd4 Bromodomain 2 in Complex with Acetylated Rel Peptide · the same entry in another collection · chain A against A, TM-score 1.00
• O60885 · AlphaFold monomer V2.0 prediction for bromodomain-containing protein 4 (O60885) · a predicted model of the same protein · chain A against A, TM-score 0.96
• Q04206 · AlphaFold monomer V2.0 prediction for transcription factor P65 (Q04206) · a predicted model of the same protein · chain B against A, TM-score 0.76

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt O60885
• Every structure of UniProt Q04206
• Elsewhere: RCSB PDB 4KV4 · PDBe 4KV4 · UniProt O60885 · UniProt Q04206