Crystal structure of human beta-galactoside alpha-2,6- sialyltransferase 1 in complex with cytidine and phosphate

Structure

x-ray diffraction · 1 distinct chain · 39% helix, 14% strand (DSSP).

Ligands and binding sites

• CTN · 4-amino-1-beta-D-ribofuranosyl-2(1H)-pyrimidinone · ligand · chains A
• NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 4 copies · chains A
• MAN · alpha-D-mannopyranose · sugar · 2 copies
• GAL · beta-D-galactopyranose · sugar · 2 copies
• BMA · beta-D-mannopyranose · sugar
• PO4 · Phosphate ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Modifications

Observed in the structure: 2 disulfide, 1 glycan (disulfide, N-glycosylation).

Compared structures

• 4JS1 · crystal structure of human Beta-galactoside alpha-2,6-sialyltransferase 1 in complex with… · the same entry in another collection · chain A against A, TM-score 1.00
• P15907 · AlphaFold monomer V2.0 prediction for beta-galactoside alpha-2,6-sialyltransferase 1… · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P15907
• Elsewhere: RCSB PDB 4JS1 · PDBe 4JS1 · UniProt P15907