Human LTC4 synthase in complex with product analogs - implications for enzyme catalysis

Structure

x-ray diffraction · 1 distinct chain · 79% helix, 0% strand (DSSP).

Ligands and binding sites

• PLM · Palmitic acid · ligand · 5 copies · chains A
• PAM · Palmitoleic acid · ligand · chains A
• GTX · S-hexylglutathione · ligand · chains A
• NI · Nickel (II) ion · metal · 3 copies · chains A
• SO4 · Sulfate ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 4JRZ · Human LTC4 synthase in complex with product analogs - implications for enzyme catalysis · the same entry in another collection · chain A against A, TM-score 1.00
• Q16873 · AlphaFold monomer V2.0 prediction for leukotriene C4 synthase (Q16873) · a predicted model of the same protein · chain A against A, TM-score 0.94

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q16873
• Elsewhere: RCSB PDB 4JRZ · PDBe 4JRZ · UniProt Q16873