Research workbench
Crystal structure of BRCA1 brct with doubly phosphorylated abraxas
Analyse Crystal structure of BRCA1 brct with doubly phosphorylated abraxas in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4JLU
- Type
- protein
- Length
- 222 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Breast cancer type 1 susceptibility protein; BRCA1-a complex subunit abraxas
- EC
- 6.3.2.-
- UniProt
- P38398, Q6UWZ7
- Pockets
- 2 · best druggability 0.44
Structure
x-ray diffraction · 2 distinct chains · 24% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Breast cancer type 1 susceptibility protein (EC 6.3.2.-) | protein | 211 | 26% helix, 14% strand | P38398 |
| B | BRCA1-a complex subunit abraxas | protein | 11 | 0% helix, 0% strand | Q6UWZ7 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 109 | 0.44 | 0.78 | 22 | empty |
| 2 | 74 | 0.41 | 0.79 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 494 Ų buried · 2 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 modified (phosphorylation).
Compared structures
- 4JLU · Crystal structure of BRCA1 BRCT with doubly phosphorylated Abraxas · the same entry in another collection · chain A against A, TM-score 1.00
- P38398 · AlphaFold monomer V2.0 prediction for breast cancer type 1 susceptibility protein (P38398) · a predicted model of the same protein · chain A against A, TM-score 0.98
- Q6UWZ7 · AlphaFold monomer V2.0 prediction for BRCA1-a complex subunit abraxas 1 (Q6UWZ7) · a predicted model of the same protein · chain B against A, TM-score 0.19
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P38398
- Every structure of UniProt Q6UWZ7
- Elsewhere: RCSB PDB 4JLU · PDBe 4JLU · UniProt P38398 · UniProt Q6UWZ7
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