UniProt P38398
Breast cancer type 1 susceptibility protein (P38398)
Breast cancer type 1 susceptibility protein (UniProt P38398), EC 2.3.2.27, 6.3.2.-: 56 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 11 pockets. Binding sites, druggability and experiment against…
- UniProt
- P38398
- Protein
- Breast cancer type 1 susceptibility protein
- EC
- 2.3.2.27, 6.3.2.-
- Experimental structures
- 56
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 11 · 1 record with a druggable one
Structures
57 records of P38398 in the MolNFT archive: 56 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1JM7 | Solution structure of the BRCA1/BARD1 RING-domain heterodimer | solution nmr | A | — | — |
| 1JM7 | Solution structure of the BRCA1/BARD1 ring-domain heterodimer | solution nmr | A | — | — |
| 1JNX | Crystal structure of the BRCT repeat region from the breast cancer associated protein, BRCA1 | x-ray diffraction | X | — | — |
| 1JNX | Crystal structure of the brct repeat region from the breast cancer associated protein, BRCA1 | x-ray diffraction | X | — | — |
| 1N5O | Structural consequences of a cancer-causing BRCA1-BRCT missense mutation | x-ray diffraction | X | — | — |
| 1N5O | Structural consequences of a cancer-causing BRCA1-brct missense mutation | x-ray diffraction | X | — | — |
| 1OQA | Solution structure of the BRCT-c domain from human BRCA1 | solution nmr | A | — | — |
| 1OQA | Solution structure of the brct-C domain from human BRCA1 | solution nmr | A | — | — |
| 1T15 | Crystal Structure of the Brca1 BRCT Domains in Complex with the Phosphorylated Interacting Region… | x-ray diffraction | A | — | — |
| 1T15 | Crystal structure of the BRCA1 brct domains in complex with the phosphorylated interacting region… | x-ray diffraction | A | — | — |
| 1T29 | Crystal structure of the BRCA1 BRCT repeats bound to a phosphorylated BACH1 peptide | x-ray diffraction | A | — | — |
| 1T29 | Crystal structure of the BRCA1 brct repeats bound to a phosphorylated BACH1 peptide | x-ray diffraction | A | — | — |
| 1T2U | Structural basis of phosphopeptide recognition by the BRCT domain of BRCA1: structure of BRCA1… | x-ray diffraction | A | — | — |
| 1T2U | Structural basis of phosphopeptide recognition by the brct domain of BRCA1: structure of BRCA1… | x-ray diffraction | A | — | — |
| 1T2V | Structural basis of phospho-peptide recognition by the BRCT domain of BRCA1, structure with… | x-ray diffraction | A, B, C, D, E | — | — |
| 1T2V | Structural basis of phospho-peptide recognition by the brct domain of BRCA1, structure with… | x-ray diffraction | A, B, C, D, E | — | — |
| 1Y98 | Structure of the BRCT repeats of BRCA1 bound to a CtIP phosphopeptide. | x-ray diffraction | A | — | — |
| 1Y98 | Structure of the brct repeats of BRCA1 bound to a ctip phosphopeptide. | x-ray diffraction | A | — | — |
| 2ING | X-ray Structure of the BRCA1 BRCT mutant M1775K | x-ray diffraction | X | — | — |
| 2ING | X-ray structure of the BRCA1 brct mutant M1775K | x-ray diffraction | X | — | — |
| 3COJ | Crystal Structure of the BRCT Domains of Human BRCA1 in Complex with a Phosphorylated Peptide from… | x-ray diffraction | X, A, B, C, D, E, F, G | — | — |
| 3COJ | Crystal structure of the brct domains of human BRCA1 in complex with a phosphorylated peptide from… | x-ray diffraction | X, A, B, C, D, E, F, G | — | — |
| 3K0H | The crystal structure of BRCA1 BRCT in complex with a minimal recognition tetrapeptide with an… | x-ray diffraction | A | — | — |
| 3K0H | The crystal structure of BRCA1 brct in complex with a minimal recognition tetrapeptide with an… | x-ray diffraction | A | — | — |
| 3K0K | Crystal Structure of BRCA1 BRCT in complex with a minimal recognition tetrapeptide with a free… | x-ray diffraction | A | — | — |
| 3K0K | Crystal structure of BRCA1 brct in complex with a minimal recognition tetrapeptide with a free… | x-ray diffraction | A | — | — |
| 3K15 | Crystal Structure of BRCA1 BRCT D1840T in complex with a minimal recognition tetrapeptide with an… | x-ray diffraction | A | — | — |
| 3K15 | Crystal structure of BRCA1 brct D1840T in complex with a minimal recognition tetrapeptide with an… | x-ray diffraction | A | — | — |
| 3K16 | Crystal Structure of BRCA1 BRCT D1840T in complex with a minimal recognition tetrapeptide with a… | x-ray diffraction | A | — | — |
| 3K16 | Crystal structure of BRCA1 brct D1840T in complex with a minimal recognition tetrapeptide with a… | x-ray diffraction | A | — | — |
| 3PXA | Impact of BRCA1 BRCT domain missense substitutions on phospho-peptide recognition: G1656D | x-ray diffraction | A | — | — |
| 3PXA | Impact of BRCA1 brct domain missense substitutions on phospho-peptide recognition: G1656D | x-ray diffraction | A | — | — |
| 3PXB | Impact of BRCA1 BRCT domain missense substitutions on phospho-peptide recognition: T1700A | x-ray diffraction | A | — | — |
| 3PXB | Impact of BRCA1 brct domain missense substitutions on phospho-peptide recognition: T1700A | x-ray diffraction | A | — | — |
| 3PXC | Impact of BRCA1 BRCT domain missense substitutions on phospho-peptide recognition: R1699Q | x-ray diffraction | X | — | — |
| 3PXC | Impact of BRCA1 brct domain missense substitutions on phospho-peptide recognition: R1699Q | x-ray diffraction | X | — | — |
| 3PXD | Impact of BRCA1 BRCT domain missense substitutions on phospho-peptide recognition: R1835P | x-ray diffraction | A | — | — |
| 3PXD | Impact of BRCA1 brct domain missense substitutions on phospho-peptide recognition: R1835P | x-ray diffraction | A | — | — |
| 3PXE | Impact of BRCA1 BRCT domain missense substitutions on phospho-peptide recognition: E1836K | x-ray diffraction | A, B, C, D | — | — |
| 3PXE | Impact of BRCA1 brct domain missense substitutions on phospho-peptide recognition: E1836K | x-ray diffraction | A, B, C, D | — | — |
| 4IFI | Structure of human BRCA1 BRCT in complex with BAAT peptide | x-ray diffraction | A | — | — |
| 4IFI | Structure of human BRCA1 brct in complex with baat peptide | x-ray diffraction | A | — | — |
| 4IGK | Structure of human BRCA1 BRCT in complex with ATRIP peptide | x-ray diffraction | A, B | — | — |
| 4IGK | Structure of human BRCA1 brct in complex with atrip peptide | x-ray diffraction | A, B | — | — |
| 4JLU | Crystal structure of BRCA1 BRCT with doubly phosphorylated Abraxas | x-ray diffraction | A | — | — |
| 4JLU | Crystal structure of BRCA1 brct with doubly phosphorylated abraxas | x-ray diffraction | A | — | — |
| 4OFB | Crystal structure of human BRCA1 BRCT in complex with nonphosphopeptide inhibitor | x-ray diffraction | A | — | — |
| 4OFB | Crystal structure of human BRCA1 brct in complex with nonphosphopeptide inhibitor | x-ray diffraction | A | — | — |
| 4U4A | Complex Structure of BRCA1 BRCT with singly phospho Abraxas | x-ray diffraction | A, B, C | — | — |
| 4U4A | Complex structure of BRCA1 brct with singly phospho abraxas | x-ray diffraction | A, B, C | — | — |
| 4Y18 | Structure of BRCA1 BRCT domains in complex with Abraxas double phosphorylated peptide | x-ray diffraction | A, B, C, D, E, F, G, H | — | 11 (best 0.78) |
| 4Y18 | Structure of BRCA1 brct domains in complex with abraxas double phosphorylated peptide | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 4Y2G | Structure of BRCA1 BRCT domains in complex with Abraxas single phosphorylated peptide | x-ray diffraction | A | — | — |
| 4Y2G | Structure of BRCA1 brct domains in complex with abraxas single phosphorylated peptide | x-ray diffraction | A | — | — |
| 6G2I | Filament of acetyl-CoA carboxylase and BRCT domains of BRCA1 (ACC-BRCT) at 5.9 A resolution | electron microscopy | H, K, M, O, S, U, Y, W | — | — |
| 7LYB | Cryo-EM structure of the human nucleosome core particle in complex with BRCA1-BARD1-UBCH5C | electron microscopy | M | ZN | — |
| P38398 | AlphaFold monomer V2.0 prediction for breast cancer type 1 susceptibility protein (P38398) | predicted | A | — | — |
Ligands
- ZN · Zinc ion · in 1 record
Experiment against prediction
- 4OFB chain A against the predicted model P38398: TM-score 0.99, RMSD 0.52 Å
- 4OFB chain A against the predicted model P38398: TM-score 0.99, RMSD 0.52 Å
- 3PXC chain X against the predicted model P38398: TM-score 0.99, RMSD 0.54 Å
- 3PXC chain X against the predicted model P38398: TM-score 0.99, RMSD 0.54 Å
- 3PXE chain D against the predicted model P38398: TM-score 0.99, RMSD 0.55 Å
- 3PXE chain D against the predicted model P38398: TM-score 0.99, RMSD 0.55 Å
- 1T2U chain A against the predicted model P38398: TM-score 0.99, RMSD 0.54 Å
- 1T2U chain A against the predicted model P38398: TM-score 0.99, RMSD 0.54 Å
- 1Y98 chain A against the predicted model P38398: TM-score 0.99, RMSD 0.57 Å
- 1Y98 chain A against the predicted model P38398: TM-score 0.99, RMSD 0.57 Å
Elsewhere
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