Calcium-calmodulin complexed with the calmodulin binding domain from a small conductance potassium channel splice variant and NS309

Structure

x-ray diffraction · 2 distinct chains · 62% helix, 5% strand (DSSP).

Ligands and binding sites

• 1KP · (3E)-6,7-dichloro-3-(hydroxyimino)-1,3-dihydro-2H-indol-2-one · ligand · chains B, R
• CA · Calcium ion · metal · 2 copies · chains R
• SO4 · Sulfate ion · ion · 4 copies · chains B, R
• GOL · Glycerol · additive · chains R

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Interfaces

1 interface between chains.

• B–R · 1355 Ų buried · 21 hydrogen bonds · protein-protein

Compared structures

• 4J9Z · Calcium-calmodulin complexed with the calmodulin binding domain from a small conductance… · the same entry in another collection · chain B against B, TM-score 1.00
• P70604 · AlphaFold monomer V2.0 prediction for small conductance calcium- activated potassium… · a predicted model of the same protein · chain B against A, TM-score 0.64

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P70604
• Every structure of UniProt P62161
• Elsewhere: RCSB PDB 4J9Z · PDBe 4J9Z · UniProt P70604 · UniProt P62161