Research workbench
Calcium-calmodulin complexed with the calmodulin binding domain from a small conductance potassium channel splice variant
Analyse Calcium-calmodulin complexed with the calmodulin binding domain from a small… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4J9Y
- Type
- protein
- Length
- 235 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Small conductance calcium-activated potassium channel protein 2; Calmodulin
- UniProt
- P70604, P62161
- Ligands
- CA, SO4
- Pockets
- 1 · best druggability 0.45
Structure
x-ray diffraction · 2 distinct chains · 64% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Small conductance calcium-activated potassium channel protein 2 | protein | 89 | 78% helix, 2% strand | P70604 |
| R | Calmodulin | protein | 146 | 55% helix, 7% strand | P62161 |
Ligands and binding sites
- CA · Calcium ion · metal · 2 copies · chains R
- SO4 · Sulfate ion · ion · 3 copies · chains B, R
- GOL · Glycerol · additive · chains R
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 80 | 0.45 | 0.81 | 17 | empty |
Interfaces
1 interface between chains.
- B–R · 1349 Ų buried · 21 hydrogen bonds · protein-protein
Compared structures
- 4J9Y · Calcium-calmodulin complexed with the calmodulin binding domain from a small conductance… · the same entry in another collection · chain B against B, TM-score 1.00
- P70604 · AlphaFold monomer V2.0 prediction for small conductance calcium- activated potassium… · a predicted model of the same protein · chain B against A, TM-score 0.68
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P70604
- Every structure of UniProt P62161
- Elsewhere: RCSB PDB 4J9Y · PDBe 4J9Y · UniProt P70604 · UniProt P62161
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