Research workbench
Structure of truncated (DELTA8C) S100A4
Analyse Structure of truncated (DELTA8C) S100A4 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4HSZ
- Type
- protein
- Length
- 360 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein S100-A4
- UniProt
- P26447
- Ligands
- CA
- Pockets
- 4 · best druggability 0.49
Structure
x-ray diffraction · 1 distinct chain · 62% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Protein S100-A4 | protein | 90 | 62% helix, 4% strand | P26447 |
Ligands and binding sites
- CA · Calcium ion · metal · 8 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 159 | 0.49 | 0.77 | 20 | empty |
| 2 | 143 | 0.47 | 0.77 | 16 | empty |
| 3 | 168 | 0.46 | 0.75 | 23 | empty |
| 4 | 149 | 0.45 | 0.75 | 17 | empty |
Interfaces
3 interfaces between chains.
- C–D · 1249 Ų buried · 12 hydrogen bonds · protein-protein
- A–B · 1238 Ų buried · 10 hydrogen bonds · protein-protein
- B–C · 175 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P26447
- Elsewhere: RCSB PDB 4HSZ · PDBe 4HSZ · UniProt P26447
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