Research workbench
Structural and electrophysiological analysis of annexin V mutants. mutagenesis of human annexin V, an in vitro voltage-gated calcium channel, provides information about the structural features of the ion pathway, the voltage sensor and the ion selectivity filter
Analyse Structural and electrophysiological analysis of annexin V mutants. mutagenesis… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1HVF
- Type
- protein
- Length
- 313 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Annexin V
- UniProt
- P08758
- Ligands
- CA, SO4
- Pockets
- 4 · best druggability 0.56
Structure
x-ray diffraction · 1 distinct chain · 72% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Annexin V | protein | 313 | 72% helix, 0% strand | P08758 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 156 | 0.56 | 0.82 | 18 | empty |
| 2 | 107 | 0.52 | 0.82 | 27 | empty |
| 3 | 103 | 0.49 | 0.81 | 23 | empty |
| 4 | 72 | 0.33 | 0.75 | 13 | empty |
Compared structures
- 1HVF · Structural and electrophysiological analysis of annexin V mutants. mutagenesis of human… · the same entry in another collection · chain A against A, TM-score 1.00
- P08758 · AlphaFold monomer V2.0 prediction for annexin A5 (P08758) · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P08758
- Elsewhere: RCSB PDB 1HVF · PDBe 1HVF · UniProt P08758
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