Research workbench
The crystal structure of human fascin 1 K41A mutant
Analyse The crystal structure of human fascin 1 K41A mutant in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4GOY
- Type
- protein
- Length
- 959 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fascin
- UniProt
- Q16658
- Ligands
- CL, BR
- Pockets
- 10 · best druggability 0.70
Structure
x-ray diffraction · 2 distinct chains · 6% helix, 49% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Fascin | protein | 475 | 6% helix, 49% strand | Q16658 |
| B | Fascin | protein | 484 | 6% helix, 48% strand | Q16658 |
Ligands and binding sites
- CL · Chloride ion · ion · 10 copies · chains A, B
- BR · Bromide ion · ion · 8 copies · chains A, B
- GOL · Glycerol · additive · 6 copies · chains A, B
- DTT · 2,3-dihydroxy-1,4-dithiobutane · additive · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
10 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 669 | 0.70 | 0.78 | 64 | empty |
| 2 | 213 | 0.53 | 0.77 | 37 | empty |
| 3 | 204 | 0.53 | 0.78 | 35 | GOL |
| 4 | 90 | 0.48 | 0.81 | 20 | empty |
| 5 | 209 | 0.47 | 0.74 | 29 | empty |
Interfaces
1 interface between chains.
- A–B · 583 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q16658
- Elsewhere: RCSB PDB 4GOY · PDBe 4GOY · UniProt Q16658
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.