UniProt Q16658
Q16658
Q16658 (UniProt Q16658): 27 experimental structures and 1 predicted model on GenesisL1, 11 ligands bound. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q16658
- Experimental structures
- 27
- Predicted models
- 1
- Ligands
- 11
Structures
28 records of Q16658 in the MolNFT archive: 27 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1DFC | Crystal structure of human fascin, an actin-crosslinking protein | x-ray diffraction | A, B | — | — |
| 1DFC | Crystal structure of human fascin, an actin-crosslinking protein | x-ray diffraction | A, B | — | — |
| 3LLP | 1.8 Angstrom human fascin 1 crystal structure | x-ray diffraction | A, B | — | — |
| 3LLP | 1.8 ångström human fascin 1 crystal structure | x-ray diffraction | A, B | — | — |
| 3P53 | Structure of fascin | x-ray diffraction | A, B | — | — |
| 3P53 | Structure of fascin | x-ray diffraction | A, B | — | — |
| 4GOV | The crystal structure of human fascin 1 S39D mutant | x-ray diffraction | A, B | — | — |
| 4GOV | The crystal structure of human fascin 1 S39D mutant | x-ray diffraction | A, B | — | — |
| 4GOY | The crystal structure of human fascin 1 K41A mutant | x-ray diffraction | A, B | — | — |
| 4GOY | The crystal structure of human fascin 1 K41A mutant | x-ray diffraction | A, B | — | — |
| 4GP0 | The crystal structure of human fascin 1 R149A K150A R151A mutant | x-ray diffraction | A, B | — | — |
| 4GP0 | The crystal structure of human fascin 1 R149A K150A R151A mutant | x-ray diffraction | A, B | — | — |
| 4GP3 | The crystal structure of human fascin 1 K358A mutant | x-ray diffraction | A, B | — | — |
| 4GP3 | The crystal structure of human fascin 1 K358A mutant | x-ray diffraction | A, B | — | — |
| 6B0T | Structural insights into the induced-fit inhibition of fascin by a small molecule | x-ray diffraction | A, B, C, D, E, F | C7V | — |
| 6I0Z | Crystal structure of fascin in complex with compound 1 | x-ray diffraction | A, B | GZQ | — |
| 6I10 | Crystal structure of fascin in complex with compound 2 | x-ray diffraction | A | GZK | — |
| 6I11 | Crystal structure of fascin in complex with compound 3 | x-ray diffraction | A | H0H | — |
| 6I12 | Crystal structure of fascin in complex with compound 5 | x-ray diffraction | A | H08 | — |
| 6I13 | Crystal structure of fascin in complex with compound 7 | x-ray diffraction | A | H0Q | — |
| 6I14 | Crystal structure of fascin in complex with compound 9 | x-ray diffraction | A | GZN | — |
| 6I15 | Crystal structure of fascin in complex with compound 11 | x-ray diffraction | A | GZT | — |
| 6I16 | Crystal structure of fascin in complex with compound 15 | x-ray diffraction | A | H0B | — |
| 6I16 | Crystal structure of fascin in complex with compound 15 | x-ray diffraction | A | H0B | — |
| 6I17 | Crystal structure of fascin in complex with compound 24 | x-ray diffraction | A | GZW | — |
| 6I17 | Crystal structure of fascin in complex with compound 24 | x-ray diffraction | A | GZW | — |
| 6I18 | Crystal structure of fascin in complex with bdp-13176 | x-ray diffraction | A | H0N | — |
| Q16658 | AlphaFold monomer V2.0 prediction for fascin (Q16658) | predicted | A | — | — |
Ligands
- GZW · 2-[(3,4-dichlorophenyl)methyl]-~{N}-(1-methylpyrazol-4-yl)-1-oxidanylidene-6-piperidin-4-yl-2,7-naphthyridine-4-carboxamide · in 2 records
- H0B · 6-[(3,4-dichlorophenyl)methyl]-~{N}-(1-methylpyrazol-4-yl)-5-oxidanylidene-1,6-naphthyridine-8-carboxamide · in 2 records
- C7V · 4-methyl-N-(1-{[4-(trifluoromethyl)phenyl]methyl}-1H-indazol-3-yl)-1,2-oxazole-5-carboxamide · in 1 record
- GZK · 1-[(3~{R})-1,1-bis(oxidanylidene)thiolan-3-yl]-5-[(3,4-dichlorophenyl)methyl]pyrazolo[3,4-d]pyrimidin-4-one · in 1 record
- GZN · 2-[(3,4-dichlorophenyl)methyl]-~{N}-(1-methylpyrazol-4-yl)-1-oxidanylidene-isoquinoline-4-carboxamide · in 1 record
- GZQ · ~{N}-(2,4-dichlorophenyl)-~{N}-methyl-ethanamide · in 1 record
- GZT · 1-[[2,2-bis(fluoranyl)-1,3-benzodioxol-5-yl]methyl]-~{N}-methyl-2-oxidanylidene-pyridine-3-carboxamide · in 1 record
- H08 · 2-[(4-chlorophenyl)methyl]-~{N}-(1-methylpyrazol-4-yl)-1-oxidanylidene-isoquinoline-4-carboxamide · in 1 record
- H0H · ~{N}-(1-methylpyrazol-4-yl)-1-oxidanylidene-2-(phenylmethyl)isoquinoline-4-carboxamide · in 1 record
- H0N · 5-[(3,4-dichlorophenyl)methyl]-4-oxidanylidene-1-piperidin-4-yl-~{N}-pyridin-4-yl-pyrazolo[4,3-c]pyridine-7-carboxamide · in 1 record
- H0Q · 2-[(3-chlorophenyl)methyl]-~{N}-(1-methylpyrazol-4-yl)-1-oxidanylidene-isoquinoline-4-carboxamide · in 1 record
Experiment against prediction
- 4GP0 chain A against the predicted model Q16658: TM-score 0.97, RMSD 1.32 Å
- 4GP0 chain A against the predicted model Q16658: TM-score 0.97, RMSD 1.32 Å
- 3LLP chain A against the predicted model Q16658: TM-score 0.97, RMSD 1.32 Å
- 3LLP chain A against the predicted model Q16658: TM-score 0.97, RMSD 1.32 Å
- 1DFC chain B against the predicted model Q16658: TM-score 0.97, RMSD 1.33 Å
- 1DFC chain B against the predicted model Q16658: TM-score 0.97, RMSD 1.33 Å
- 4GP3 chain A against the predicted model Q16658: TM-score 0.97, RMSD 1.37 Å
- 4GP3 chain A against the predicted model Q16658: TM-score 0.97, RMSD 1.37 Å
- 3P53 chain B against the predicted model Q16658: TM-score 0.97, RMSD 1.41 Å
- 3P53 chain B against the predicted model Q16658: TM-score 0.97, RMSD 1.41 Å
Elsewhere
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