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Crystal structure of CA2+/CAM:KV7.4 (KCNQ4) B helix complex

Analyse Crystal structure of CA2+/CAM:KV7.4 (KCNQ4) B helix complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4GOW
Type: protein
Length: 168 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Calmodulin; Potassium voltage-gated channel subfamily kqt member 4
UniProt: P62158, P56696
Ligands: CA

Structure

x-ray diffraction · 2 distinct chains · 64% helix, 4% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
D	Calmodulin	protein	142	60% helix, 4% strand	P62158
A	Potassium voltage-gated channel subfamily kqt member 4	protein	26	88% helix, 0% strand	P56696

Ligands and binding sites

CA · Calcium ion · metal · 4 copies · chains D

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

D–A · 1533 Å² buried · 11 hydrogen bonds · protein-protein

Compared structures

4GOW · Crystal Structure of Ca2+/CaM:Kv7.4 (KCNQ4) B helix complex · the same entry in another collection · chain D against D, TM-score 1.00
P56696 · AlphaFold monomer V2.0 prediction for potassium voltage-gated channel subfamily kqt… · a predicted model of the same protein · chain A against A, TM-score 0.75

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P62158
Every structure of UniProt P56696
Elsewhere: RCSB PDB 4GOW · PDBe 4GOW · UniProt P62158 · UniProt P56696

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