Research workbench
Crystal structure of the spop btb domain complexed with the CUL3 N- terminal domain
Analyse Crystal structure of the spop btb domain complexed with the CUL3 N- terminal… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4EOZ
- Type
- protein
- Length
- 833 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Speckle-type poz protein; Cullin-3
- UniProt
- O43791, Q13618
- Pockets
- 3 · best druggability 0.50
Structure
x-ray diffraction · 4 distinct chains · 74% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Speckle-type poz protein | protein | 114 | 57% helix, 12% strand | O43791 |
| C | Speckle-type poz protein | protein | 116 | 59% helix, 12% strand | O43791 |
| B | Cullin-3 | protein | 302 | 80% helix, 0% strand | Q13618 |
| D | Cullin-3 | protein | 301 | 79% helix, 0% strand | Q13618 |
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 92 | 0.50 | 0.82 | 25 | empty |
| 2 | 77 | 0.46 | 0.82 | 20 | empty |
| 3 | 50 | 0.23 | 0.72 | 14 | empty |
Interfaces
3 interfaces between chains.
- A–C · 1364 Ų buried · 10 hydrogen bonds · protein-protein
- C–D · 866 Ų buried · 14 hydrogen bonds · protein-protein
- A–B · 858 Ų buried · 12 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 36 modified (engineered).
Compared structures
- 4EOZ · Crystal structure of the SPOP BTB domain complexed with the Cul3 N-terminal domain · the same entry in another collection · chain A against A, TM-score 1.00
- O43791 · AlphaFold monomer V2.0 prediction for speckle-type poz protein (O43791) · a predicted model of the same protein · chain C against A, TM-score 0.99
- Q13618 · AlphaFold monomer V2.0 prediction for cullin-3 (Q13618) · a predicted model of the same protein · chain B against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O43791
- Every structure of UniProt Q13618
- Elsewhere: RCSB PDB 4EOZ · PDBe 4EOZ · UniProt O43791 · UniProt Q13618
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