UniProt Q13618
Cullin-3 (Q13618)
Cullin-3 (UniProt Q13618): 33 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 195 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q13618
- Protein
- Cullin-3
- Experimental structures
- 33
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 195 · 17 records with a druggable one
Structures
34 records of Q13618 in the MolNFT archive: 33 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2MYL | Cullin3 - BTB interface: a novel target for stapled peptides | solution nmr | A | — | — |
| 2MYL | CULLIN3 - btb interface: a novel target for stapled peptides | solution nmr | A | — | — |
| 2MYM | Cullin3 - BTB interface: a novel target for stapled peptides | solution nmr | A | — | — |
| 2MYM | CULLIN3 - btb interface: a novel target for stapled peptides | solution nmr | A | — | — |
| 4AP2 | Crystal structure of the human KLHL11-Cul3 complex at 2.8A resolution | x-ray diffraction | B | — | — |
| 4AP2 | Crystal structure of the human KLHL11-CUL3 complex at 2.8A resolution | x-ray diffraction | B | — | — |
| 4APF | Crystal structure of the human KLHL11-Cul3 complex at 3.1A resolution | x-ray diffraction | B | — | — |
| 4APF | Crystal structure of the human KLHL11-CUL3 complex at 3.1A resolution | x-ray diffraction | B | — | — |
| 4EOZ | Crystal structure of the SPOP BTB domain complexed with the Cul3 N-terminal domain | x-ray diffraction | B, D | — | — |
| 4EOZ | Crystal structure of the spop btb domain complexed with the CUL3 N- terminal domain | x-ray diffraction | B, D | — | — |
| 4HXI | Crystal structure of KLHL3/Cul3 complex | x-ray diffraction | B | — | — |
| 4HXI | Crystal structure of KLHL3/CUL3 complex | x-ray diffraction | B | — | — |
| 5NLB | Crystal structure of human CUL3 N-terminal domain bound to KEAP1 BTB and 3-box | x-ray diffraction | B | — | — |
| 5NLB | Crystal structure of human CUL3 N-terminal domain bound to KEAP1 btb and 3-box | x-ray diffraction | B | — | — |
| 6I2M | Crystal structure of vaccinia virus protein A55 btb-back domain in complex with human cullin-3… | x-ray diffraction | B | — | — |
| 8GQ6 | Cryo-EM Structure of the KBTBD2-CUL3-Rbx1 dimeric complex | electron microscopy | C, F | ZN | 11 (best 0.78) |
| 8H33 | Cryo-EM Structure of the KBTBD2-Cul3-Rbx1 tetrameric complex | electron microscopy | F, H, I, C | ZN | 14 (best 0.83) |
| 8H34 | Cryo-EM Structure of the KBTBD2-Cul3-Rbx1 hexameric complex | electron microscopy | M, O, C, F, I, H | ZN | 14 (best 0.82) |
| 8H35 | Cryo-EM Structure of the KBTBD2-Cul3-Rbx1 octameric complex | electron microscopy | C, F, I, H, M, O, T, V | ZN | 12 (best 0.81) |
| 8H36 | Cryo-EM Structure of the KBTBD2-CUL3-Rbx1-p85a dimeric complex | electron microscopy | C, F | ZN | 10 (best 0.80) |
| 8H37 | Cryo-EM Structure of the KBTBD2-CUL3-Rbx1-p85a tetrameric complex | electron microscopy | C, F, M, O | ZN | 15 (best 0.84) |
| 8H3A | Cryo-EM Structure of the KBTBD2-CRL3~N8(removed)-CSN complex | electron microscopy | L | — | 9 (best 0.78) |
| 8H3F | Cryo-EM Structure of the KBTBD2-CRL3-CSN complex | electron microscopy | L | — | 8 (best 0.84) |
| 8H3Q | Cryo-EM Structure of the CAND1-Cul3-Rbx1 complex | electron microscopy | C | — | 17 (best 0.85) |
| 8H3R | Cryo-EM Structure of the KBTBD2-CRL3~N8 dimeric complex | electron microscopy | C, F | — | 13 (best 0.79) |
| 8I79 | Cryo-EM structure of KCTD7 in complex with Cullin3 | electron microscopy | B, C, E, H, J | — | 19 (best 0.76) |
| 8K8T | Structure of CUL3-RBX1-KLHL22 complex | electron microscopy | C, D | — | 7 (best 0.49) |
| 8K9I | Structure of CUL3-RBX1-KLHL22 complex without CUL3 NA motif | electron microscopy | C | — | 4 (best 0.57) |
| 8KHP | CULLIN3-KLHL22-RBX1 E3 ligase | electron microscopy | C, D | — | 9 (best 0.79) |
| 8U80 | KCTD5/Cullin3/Gbeta1gamma2 Complex: Local Refinment of KCTD5(BTB)/Cullin3(NTD) | electron microscopy | C1, C2, C3, C4, C5 | — | 16 (best 0.67) |
| 8U82 | KCTD5/Cullin3/Gbeta1gamma2 Complex: State B From Composite RELION Multi-body Refinement Map | electron microscopy | C1, C2, C3, C4, C5 | — | 5 (best 0.73) |
| 8U83 | KCTD5/Cullin3/Gbeta1gamma2 Complex: State C From Composite RELION Multi-body Refinement Map | electron microscopy | C1, C2, C3, C4, C5 | — | 7 (best 0.80) |
| 8U84 | KCTD5/Cullin3/Gbeta1gamma2 Complex: State D From Composite RELION Multi-body Refinement Map | electron microscopy | C1, C2, C3, C4, C5 | — | 5 (best 0.72) |
| Q13618 | AlphaFold monomer V2.0 prediction for cullin-3 (Q13618) | predicted | A | — | — |
Ligands
- ZN · Zinc ion · in 6 records
Experiment against prediction
- 4APF chain B against the predicted model Q13618: TM-score 0.99, RMSD 0.74 Å
- 4APF chain B against the predicted model Q13618: TM-score 0.99, RMSD 0.74 Å
- 4HXI chain B against the predicted model Q13618: TM-score 0.98, RMSD 0.98 Å
- 4HXI chain B against the predicted model Q13618: TM-score 0.98, RMSD 0.98 Å
- 6I2M chain B against the predicted model Q13618: TM-score 0.98, RMSD 1.13 Å
- 4EOZ chain B against the predicted model Q13618: TM-score 0.98, RMSD 1.12 Å
- 4EOZ chain B against the predicted model Q13618: TM-score 0.98, RMSD 1.12 Å
- 5NLB chain B against the predicted model Q13618: TM-score 0.98, RMSD 1.06 Å
- 5NLB chain B against the predicted model Q13618: TM-score 0.98, RMSD 1.06 Å
- 8K9I chain C against the predicted model Q13618: TM-score 0.98, RMSD 1.47 Å
Elsewhere
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