Research workbench
Structure of the inactive retinoblastoma protein pocket domain
Analyse Structure of the inactive retinoblastoma protein pocket domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4ELL
- Type
- protein
- Length
- 680 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Retinoblastoma-associated protein
- UniProt
- P06400
- Pockets
- 11 · best druggability 0.60
Structure
x-ray diffraction · 2 distinct chains · 70% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Retinoblastoma-associated protein | protein | 331 | 71% helix, 1% strand | P06400 |
| B | Retinoblastoma-associated protein | protein | 349 | 69% helix, 2% strand | P06400 |
Pockets
11 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 435 | 0.60 | 0.75 | 54 | empty |
| 2 | 172 | 0.49 | 0.77 | 30 | empty |
| 3 | 57 | 0.37 | 0.79 | 19 | empty |
| 4 | 96 | 0.35 | 0.74 | 13 | empty |
| 5 | 54 | 0.33 | 0.78 | 20 | empty |
Interfaces
1 interface between chains.
- A–B · 243 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 4ELL · Structure of the inactive retinoblastoma protein pocket domain · the same entry in another collection · chain A against A, TM-score 1.00
- P06400 · AlphaFold monomer V2.0 prediction for retinoblastoma-associated protein (P06400) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P06400
- Elsewhere: RCSB PDB 4ELL · PDBe 4ELL · UniProt P06400
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