Structure of human regulator of G protein signaling 2 (RGS2) in complex with murine galpha-Q(R183C)

Structure

x-ray diffraction · 2 distinct chains · 56% helix, 9% strand (DSSP).

Ligands and binding sites

• GDP · Guanosine-5'-diphosphate · ligand · chains A
• ALF · Tetrafluoroaluminate ion · ligand · chains A
• CO · Cobalt (II) ion · metal · 2 copies · chains A
• MG · Magnesium ion · metal · chains A
• CL · Chloride ion · ion · 2 copies · chains A
• MES · 2-(N-morpholino)-ethanesulfonic acid · additive · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Interfaces

1 interface between chains.

• A–B · 1113 Ų buried · 13 hydrogen bonds · protein-protein

Compared structures

• 4EKD · Structure of human regulator of G protein signaling 2 (RGS2) in complex with murine… · the same entry in another collection · chain A against A, TM-score 1.00
• P21279 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(Q) subunit… · a predicted model of the same protein · chain A against A, TM-score 0.98
• P41220 · AlphaFold monomer V2.0 prediction for regulator of G-protein signaling 2 (P41220) · a predicted model of the same protein · chain B against A, TM-score 0.98

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P21279
• Every structure of UniProt P41220
• Elsewhere: RCSB PDB 4EKD · PDBe 4EKD · UniProt P21279 · UniProt P41220