Research workbench
Structure of human regulator of G protein signaling 2 (RGS2) in complex with murine galpha-Q(R183C)
Analyse Structure of human regulator of G protein signaling 2 (RGS2) in complex with… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4EKC
- Type
- protein
- Length
- 890 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Guanine nucleotide-binding protein G(Q) subunit alpha; Regulator of G-protein signaling 2
- EC
- 3.6.5.1
- UniProt
- P21279, P41220
- Ligands
- GDP, ALF, MG
- Pockets
- 6 · best druggability 0.84
Structure
x-ray diffraction · 2 distinct chains · 54% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Guanine nucleotide-binding protein G(Q) subunit alpha (EC 3.6.5.1) | protein | 317 | 49% helix, 14% strand | P21279 |
| B, D | Regulator of G-protein signaling 2 | protein | 128 | 66% helix, 0% strand | P41220 |
Ligands and binding sites
- GDP · Guanosine-5'-diphosphate · ligand · 2 copies · chains A, C
- ALF · Tetrafluoroaluminate ion · ligand · 2 copies · chains A, C
- MG · Magnesium ion · metal · 2 copies · chains A, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 871 | 0.84 | 0.86 | 84 | GDP, ALF, MG |
| 2 | 867 | 0.84 | 0.86 | 84 | GDP, ALF, MG |
| 3 | 456 | 0.67 | 0.79 | 43 | empty |
| 4 | 405 | 0.67 | 0.79 | 40 | empty |
| 5 | 69 | 0.38 | 0.78 | 15 | empty |
Interfaces
3 interfaces between chains.
- C–D · 1203 Ų buried · 14 hydrogen bonds · protein-protein
- A–B · 1192 Ų buried · 12 hydrogen bonds · protein-protein
- A–C · 724 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 4EKC · Structure of human regulator of G protein signaling 2 (RGS2) in complex with murine… · the same entry in another collection · chain A against A, TM-score 1.00
- P21279 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(Q) subunit… · a predicted model of the same protein · chain A against A, TM-score 0.98
- P41220 · AlphaFold monomer V2.0 prediction for regulator of G-protein signaling 2 (P41220) · a predicted model of the same protein · chain B against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P21279
- Every structure of UniProt P41220
- Elsewhere: RCSB PDB 4EKC · PDBe 4EKC · UniProt P21279 · UniProt P41220
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.