Research workbench
Crystal structure of the HMHF1/HMHF2 histone-fold tetramer
Analyse Crystal structure of the HMHF1/HMHF2 histone-fold tetramer in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4E44
- Type
- protein
- Length
- 351 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Centromere protein S; Centromere protein X
- UniProt
- Q8N2Z9, A8MT69
- Pockets
- 2 · best druggability 0.58
Structure
x-ray diffraction · 3 distinct chains · 76% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Centromere protein S | protein | 104 | 81% helix, 4% strand | Q8N2Z9 |
| C | Centromere protein S | protein | 97 | 76% helix, 3% strand | Q8N2Z9 |
| B, D | Centromere protein X | protein | 75 | 68% helix, 5% strand | A8MT69 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 165 | 0.58 | 0.82 | 28 | empty |
| 2 | 92 | 0.34 | 0.74 | 18 | empty |
Interfaces
6 interfaces between chains.
- C–D · 2385 Ų buried · 18 hydrogen bonds · protein-protein
- A–B · 2304 Ų buried · 18 hydrogen bonds · protein-protein
- A–C · 633 Ų buried · 17 hydrogen bonds · protein-protein
- B–D · 142 Ų buried · 0 hydrogen bonds · protein-protein
- A–D · 33 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 4E44 · Crystal structure of the hMHF1/hMHF2 Histone-Fold Tetramer · the same entry in another collection · chain D against D, TM-score 1.00
- A8MT69 · AlphaFold monomer V2.0 prediction for centromere protein X (A8MT69) · a predicted model of the same protein · chain B against A, TM-score 0.98
- Q8N2Z9 · AlphaFold monomer V2.0 prediction for centromere protein S (Q8N2Z9) · a predicted model of the same protein · chain A against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8N2Z9
- Every structure of UniProt A8MT69
- Elsewhere: RCSB PDB 4E44 · PDBe 4E44 · UniProt Q8N2Z9 · UniProt A8MT69
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