Research workbench
O-crystal structure of the ppiase domain of FKBP52, rapamycin and the frb fragment of mtor
Analyse O-crystal structure of the ppiase domain of FKBP52, rapamycin and the frb… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4DRJ
- Type
- protein
- Length
- 217 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Peptidyl-prolyl cis-trans isomerase FKBP4; SERINE/THREONINE-protein kinase mtor
- EC
- 5.2.1.8, 2.7.11.1
- UniProt
- Q02790, P42345
- Ligands
- RAP, SO4
- Pockets
- 1 · best druggability 0.75
Structure
x-ray diffraction · 2 distinct chains · 43% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Peptidyl-prolyl cis-trans isomerase FKBP4 (EC 5.2.1.8) | protein | 121 | 8% helix, 38% strand | Q02790 |
| B | SERINE/THREONINE-protein kinase mtor (EC 2.7.11.1) | protein | 96 | 86% helix, 0% strand | P42345 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 678 | 0.75 | 0.80 | 48 | RAP |
Interfaces
1 interface between chains.
- A–B · 315 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 4DRJ · o-crystal structure of the PPIase domain of FKBP52, Rapamycin and the FRB fragment of mTOR · the same entry in another collection · chain A against A, TM-score 1.00
- Q02790 · AlphaFold monomer V2.0 prediction for peptidyl-prolyl cis-trans isomerase FKBP4 (Q02790) · a predicted model of the same protein · chain A against A, TM-score 0.98
- P42345 · AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase mtor (P42345) · a predicted model of the same protein · chain B against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q02790
- Every structure of UniProt P42345
- Elsewhere: RCSB PDB 4DRJ · PDBe 4DRJ · UniProt Q02790 · UniProt P42345
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