Research workbench

1.35 a crystal structure of the NAV1.5 diii-IV-CA/CAM complex

Analyse 1.35 a crystal structure of the NAV1.5 diii-IV-CA/CAM complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4DJC
Type: protein
Length: 164 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Calmodulin; Sodium channel protein type 5 subunit alpha
UniProt: P62158, Q14524
Ligands: CA

Structure

x-ray diffraction · 2 distinct chains · 65% helix, 5% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Calmodulin	protein	151	63% helix, 5% strand	P62158
B	Sodium channel protein type 5 subunit alpha	protein	13	85% helix, 0% strand	Q14524

Ligands and binding sites

CA · Calcium ion · metal · 4 copies · chains A
IPA · Isopropyl alcohol · additive · 9 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

A–B · 770 Å² buried · 7 hydrogen bonds · protein-protein

Compared structures

4DJC · 1.35 A crystal structure of the NaV1.5 DIII-IV-Ca/CaM complex · the same entry in another collection · chain A against A, TM-score 1.00
Q14524 · AlphaFold monomer V2.0 prediction for sodium channel protein type 5 subunit alpha (Q14524) · a predicted model of the same protein · chain B against A, TM-score 0.81

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P62158
Every structure of UniProt Q14524
Elsewhere: RCSB PDB 4DJC · PDBe 4DJC · UniProt P62158 · UniProt Q14524

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