UniProt Q14524
Sodium channel protein type 5 subunit alpha (Q14524)
Sodium channel protein type 5 subunit alpha (UniProt Q14524): 16 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 20 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- Q14524
- Protein
- Sodium channel protein type 5 subunit alpha
- Experimental structures
- 16
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 20 · 1 record with a druggable one
Structures
17 records of Q14524 in the MolNFT archive: 16 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2KBI | Solution NMR structure of the C-terminal EF-hand domain of human cardiac sodium channel NaV1.5 | solution nmr | A | — | — |
| 2KBI | Solution NMR structure of the C-terminal ef-hand domain of human cardiac sodium channel NAV1.5 | solution nmr | A | — | — |
| 4DCK | Crystal structure of the C-terminus of voltage-gated sodium channel in complex with FGF13 and CaM | x-ray diffraction | A | — | — |
| 4DCK | Crystal structure of the C-terminus of voltage-gated sodium channel in complex with FGF13 and cam | x-ray diffraction | A | — | — |
| 4DJC | 1.35 A crystal structure of the NaV1.5 DIII-IV-Ca/CaM complex | x-ray diffraction | B | — | — |
| 4DJC | 1.35 a crystal structure of the NAV1.5 diii-IV-CA/CAM complex | x-ray diffraction | B | — | — |
| 4JQ0 | Voltage-gated sodium channel 1.5 C-terminal domain in complex with FGF12B and Ca2+/calmodulin | x-ray diffraction | D | — | — |
| 4JQ0 | Voltage-gated sodium channel 1.5 C-terminal domain in complex with FGF12B and CA2+/CALMODULIN | x-ray diffraction | D | — | — |
| 4OVN | Voltage-gated Sodium Channel 1.5 (Nav1.5) C-terminal domain in complex with Calmodulin poised for… | x-ray diffraction | F, G, H, I, J | — | — |
| 4OVN | Voltage-gated sodium channel 1.5 (NAV1.5) C-terminal domain in complex with calmodulin poised for… | x-ray diffraction | F, G, H, I, J | — | — |
| 5DBR | Ca2+ CaM with human cardiac Na+ channel (NaV1.5) inactivation gate | x-ray diffraction | C | — | — |
| 5DBR | CA2+ cam with human cardiac na+ channel (NAV1.5) inactivation gate | x-ray diffraction | C | — | — |
| 6LQA | Voltage-gated sodium channel NAV1.5 with quinidine | electron microscopy | B | NAG, QDN | — |
| 6MUD | Voltage-gated sodium channel NAV1.5 C-terminal domain in complex with CA2+/CALMODULIN | x-ray diffraction | B | — | — |
| 7DTC | Voltage-gated sodium channel NAV1.5-E1784K | electron microscopy | A | NAG | — |
| 7L83 | NMR solution structure of NAV1.5 div S3B-S4A paddle motif in dpc micelle | solution nmr | A | — | — |
| Q14524 | AlphaFold monomer V2.0 prediction for sodium channel protein type 5 subunit alpha (Q14524) | predicted | A | — | 20 (best 0.86) |
Ligands
Experiment against prediction
- 6LQA chain B against the predicted model Q14524: TM-score 0.98, RMSD 1.82 Å
- 7DTC chain A against the predicted model Q14524: TM-score 0.97, RMSD 1.88 Å
- 6MUD chain B against the predicted model Q14524: TM-score 0.91, RMSD 1.78 Å
- 2KBI chain A against the predicted model Q14524: TM-score 0.88, RMSD 1.93 Å
- 2KBI chain A against the predicted model Q14524: TM-score 0.88, RMSD 1.93 Å
- 4OVN chain H against the predicted model Q14524: TM-score 0.85, RMSD 2.58 Å
- 4OVN chain H against the predicted model Q14524: TM-score 0.85, RMSD 2.58 Å
- 4OVN chain F against the predicted model Q14524: TM-score 0.84, RMSD 2.38 Å
- 4OVN chain F against the predicted model Q14524: TM-score 0.84, RMSD 2.38 Å
- 4OVN chain I against the predicted model Q14524: TM-score 0.84, RMSD 2.41 Å
Elsewhere
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