Research workbench
Histone demethylase LSD1(KDM1A)-COREST3 complex
Analyse Histone demethylase LSD1(KDM1A)-COREST3 complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4CZZ
- Type
- protein
- Length
- 799 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Lysine-specific histone demethylase 1A; Rest corepressor 3
- EC
- 1.-.-.-
- UniProt
- O60341, Q9P2K3
- Ligands
- FAD
- Pockets
- 10 · best druggability 0.82
Structure
x-ray diffraction · 2 distinct chains · 48% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Lysine-specific histone demethylase 1A (EC 1.-.-.-) | protein | 666 | 45% helix, 15% strand | O60341 |
| B | Rest corepressor 3 | protein | 133 | 64% helix, 0% strand | Q9P2K3 |
Ligands and binding sites
- FAD · Flavin-adenine dinucleotide · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
10 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 958 | 0.82 | 0.84 | 92 | FAD |
| 2 | 355 | 0.63 | 0.79 | 30 | empty |
| 3 | 218 | 0.49 | 0.75 | 23 | empty |
| 4 | 125 | 0.46 | 0.78 | 29 | empty |
| 5 | 95 | 0.45 | 0.79 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 2626 Ų buried · 16 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O60341
- Every structure of UniProt Q9P2K3
- Elsewhere: RCSB PDB 4CZZ · PDBe 4CZZ · UniProt O60341 · UniProt Q9P2K3
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