Research workbench
Complex of neurospora crassa PAN2 (WD40) with PAN3 (C-term)
Analyse Complex of neurospora crassa PAN2 (WD40) with PAN3 (C-term) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4CZX
- Type
- protein
- Length
- 427 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Pab-dependent POLY(A)-specific ribonuclease subunit PAN2; Pab-dependent POLY(A)-specific…
- EC
- 3.1.13.4
- UniProt
- P0C581, Q7SDP4
- Ligands
- PO4
- Pockets
- 7 · best druggability 0.75
Structure
x-ray diffraction · 2 distinct chains · 15% helix, 39% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Pab-dependent POLY(A)-specific ribonuclease subunit PAN2 (EC 3.1.13.4) | protein | 324 | 2% helix, 48% strand | P0C581 |
| B | Pab-dependent POLY(A)-specific ribonuclease subunit PAN3 | protein | 103 | 58% helix, 12% strand | Q7SDP4 |
Ligands and binding sites
- PO4 · Phosphate ion · ion · chains A
- MES · 2-(N-morpholino)-ethanesulfonic acid · additive · chains A
- GOL · Glycerol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 728 | 0.75 | 0.80 | 58 | MES |
| 2 | 135 | 0.47 | 0.78 | 17 | empty |
| 3 | 76 | 0.40 | 0.79 | 18 | empty |
| 4 | 53 | 0.40 | 0.81 | 12 | empty |
| 5 | 109 | 0.39 | 0.75 | 23 | empty |
Interfaces
1 interface between chains.
- A–B · 732 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 4CZX · Complex of Neurospora crassa PAN2 (WD40) with PAN3 (C-TERM) · the same entry in another collection · chain A against A, TM-score 1.00
- P0C581 · AlphaFold monomer V2.0 prediction for PAN2-PAN3 deadenylation complex catalytic subunit… · a predicted model of the same protein · chain A against A, TM-score 0.95
- Q7SDP4 · AlphaFold monomer V2.0 prediction for PAN2-PAN3 deadenylation complex subunit PAN3… · a predicted model of the same protein · chain B against A, TM-score 0.91
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0C581
- Every structure of UniProt Q7SDP4
- Elsewhere: RCSB PDB 4CZX · PDBe 4CZX · UniProt P0C581 · UniProt Q7SDP4
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