Research workbench
Structure of the neurospora crassa PAN2 WD40 domain
Analyse Structure of the neurospora crassa PAN2 WD40 domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4CZV
- Type
- protein
- Length
- 648 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Pab-dependent POLY(A)-specific ribonuclease subunit PAN2
- EC
- 3.1.13.4
- UniProt
- P0C581
- Ligands
- CL
- Pockets
- 3 · best druggability 0.79
Structure
x-ray diffraction · 1 distinct chain · 2% helix, 48% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Pab-dependent POLY(A)-specific ribonuclease subunit PAN2 (EC 3.1.13.4) | protein | 324 | 2% helix, 48% strand | P0C581 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 743 | 0.79 | 0.83 | 61 | empty |
| 2 | 750 | 0.78 | 0.82 | 74 | empty |
| 3 | 955 | 0.74 | 0.77 | 58 | empty |
Interfaces
1 interface between chains.
- A–B · 365 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 4CZV · Structure of the Neurospora crassa Pan2 WD40 domain · the same entry in another collection · chain A against A, TM-score 1.00
- P0C581 · AlphaFold monomer V2.0 prediction for PAN2-PAN3 deadenylation complex catalytic subunit… · a predicted model of the same protein · chain A against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0C581
- Elsewhere: RCSB PDB 4CZV · PDBe 4CZV · UniProt P0C581
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.