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Crystal structure of the complex of the cellular retinal binding protein with 9-cis-retinal

Analyse Crystal structure of the complex of the cellular retinal binding protein with… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4CIZ
Type: protein
Length: 284 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Retinaldehyde-binding protein 1
UniProt: P12271
Ligands: RET
Pockets: 3 · best druggability 0.84

Structure

x-ray diffraction · 1 distinct chain · 48% helix, 11% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Retinaldehyde-binding protein 1	protein	284	48% helix, 11% strand	P12271

Ligands and binding sites

RET · Retinal · ligand · chains A
TLA · L(+)-tartaric acid · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	209	0.84	0.96	27	RET
2	93	0.56	0.85	20	TLA
3	58	0.38	0.79	17	empty

Compared structures

4CIZ · Crystal structure of the complex of the Cellular Retinal Binding Protein with… · the same entry in another collection · chain A against A, TM-score 1.00
P12271 · AlphaFold monomer V2.0 prediction for retinaldehyde-binding protein 1 (P12271) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P12271
Elsewhere: RCSB PDB 4CIZ · PDBe 4CIZ · UniProt P12271

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