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Ligand · TLA

TLA · L(+)-tartaric acid

TLA, L(+)-tartaric acid (C4 H6 O6, 150.1 g/mol), in the MolNFT structures on GenesisL1: bound in 294 records (229 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the ligands found with it.

Component
TLA
Formula
C4 H6 O6
Class
additive
Structures
294
PDB entries
229

Binding sites

TLA in 294 structures; the first of them:

  • 4XVB · Recombinant thaumatin in the presence of 1.5M PST at 293K · TLA A301 · binds ARG29, GLY34, GLU35, SER36
  • 5DWF · Crystal structure of the complex of Peptidoglycan recognition protein, PGRP-S from camel… · TLA C201 · binds HIS37, ALA39, THR152, LEU153, SER154, HIS37, ALA39, THR152 and 2 more
  • 5E0A · Crystal Structure of the complex of Camel Peptidoglycan Recognition Protein (CPGRP-S) and… · TLA C202 · binds HIS37, ALA39, MET112, THR152, LEU153, SER154, HIS37, ALA39 and 3 more
  • 5E0B · Crystal structure of the complex of Peptidoglycan recognition protein PGRP-S with… · TLA C201 · binds HIS37, ALA39, THR152, LEU153, SER154, HIS37, ALA39, THR152 and 2 more
  • 5EE7 · Crystal structure of the human glucagon receptor (GCGR) in complex with the antagonist… · TLA A1217 · binds ILE315, ASN318, PHE319, ILE355, PRO356, GLY359, VAL360
  • 5FGT · Thaumatin solved by native sulphur-SAD using free-electron laser radiation · TLA A301 · binds ARG29, GLU35, SER36
  • 5H9Y · Crystal structure of GH family 64 laminaripentaose-producing beta-1,3-glucanase from… · TLA A510 · binds SER44, GLU53, HIS54, THR55
  • 5HD0 · BACE-1 in complex with (7aR)-7a-(4-(3-cyanophenyl)thiophen-2-yl)-6-(5-fluoropyrimidin-2-yl… · TLA A501 · binds ARG68, ASN89, HIS110, ARG111, ASN175
  • 5HDU · BACE-1 incomplex with (7aR)-7a-(4-(3-cyanophenyl)thiophen-2-yl)-6-(5-fluoro-4-methoxypyrim… · TLA A501 · binds ARG68, ASN89, HIS110, ARG111, ASN175, GLU177, LEU228
  • 5HDV · BACE-1 incomplex with (7aR)-7a-(5-cyanothiophen-2-yl)-6-(5-fluoro-4-methoxy-6-methylpyrimi… · TLA B501 · binds ARG68, ASN89, HIS110, ARG111, ASN175
  • 5HE5 · BACE-1 in complex with (7aR)-7a-(5-cyanothiophen-2-yl)-6-(5-fluoro-4-methyl-6-(methylamino… · TLA A501 · binds ARG68, ASN89, HIS110, ARG111, ASN175
  • 5HU0 · BACE1 in complex with 4-(3-(furan-2-carboxamido)phenyl)-1-methyl-5-oxo-4-phenylimidazolidi… · TLA A501 · binds ARG68, ASN89, HIS110, ARG111, ASN175
  • 5HYG · CmlI (peroxo bound state), arylamine oxygenase of chloramphenicol biosynthetic pathway · TLA A403 · binds ASN209, ALA210, ASP213, ASP312, SER314, GLY315
  • 5HYH · CmlI (chemically reduced state), arylamine oxygenase of chloramphenicol biosynthetic… · TLA A403 · binds ASN209, ALA210, ASP213, ASP312, SER314, GLY315
  • 5J42 · Crystal structure of m2hTDP2-CAT in complex with a small molecule inhibitor · TLA A402 · binds THR240, ARG241, GLY242, PRO318, ALA319, ALA320
  • 5JHT · Apo form of influenza strain H1N1 polymerase acidic subunit N-terminal region… · TLA A303 · binds HIS41, GLU80, ASP108, GLU119, ILE120, GLY121, TYR130, LYS134
  • 5JVX · X-ray structure of the adduct formed in the reaction between thaumatin and a gold carbene… · TLA A501 · binds GLY96, LYS97, PRO194, GLY195
  • 5KVX · T. danielli thaumatin at 100K, Data set 2 · TLA A301 · binds ARG29, GLU35, SER36
  • 5KVZ · T. danielli thaumatin at 100K, Data set 3 · TLA A301 · binds ARG29, GLY34, GLU35, SER36
  • 5KW3 · T. danielli thaumatin at 278K, Data set 1 · TLA A301 · binds ARG29, GLU35, SER36
  • 5KW5 · T. danielli thaumatin at 278K, Data set 3 · TLA A301 · binds ARG29, GLU35, SER36
  • 5KW7 · T. danielli thaumatin at 278K, Data set 4 · TLA A301 · binds ARG29, GLY34, GLU35, SER36
  • 5KYV · Structure of Photinus pyralis Luciferase green shifted light emitting variant · TLA A602 · binds PRO225, ASN229, GLN230, HIS310, GLU311, GLU354
  • 5LH1 · Low dose Thaumatin - 360-400 ms. · TLA A301 · binds PHE152, THR154, TYR157, TYR169
  • 5LH6 · High dose Thaumatin - 360-400 ms. · TLA A301 · binds TYR157
  • 5LH7 · High dose Thaumatin - 760-800 ms. · TLA A301 · binds PHE152, TYR157, TYR169
  • 5M9V · Human angiogenin PD/ALS variant R121C · TLA A301 · binds GLY99, PHE100, ARG101

Residues it binds most

ARG 372, HIS 240, SER 282, GLY 164, GLU 189, LEU 147, ALA 130, ASN 154, THR 140, LYS 111 (residue and the binding sites it lines).

Found with

  • GOL · Glycerol
  • EDO · 1,2-ethanediol
  • SO4 · Sulfate ion
  • DMS · Dimethyl sulfoxide
  • LU8 · 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine
  • CL · Chloride ion
  • ACT · Acetate ion
  • NA · Sodium ion
  • MG · Magnesium ion
  • MN · Manganese (II) ion
  • ZN · Zinc ion
  • FAD · Flavin-adenine dinucleotide

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