Notch ligand, jagged-1, contains an N-terminal C2 domain

Structure

x-ray diffraction · 2 distinct chains · 1% helix, 41% strand (DSSP).

Ligands and binding sites

• NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 2 copies · chains A, B
• FUC · alpha-L-fucopyranose · sugar · chains A
• CA · Calcium ion · metal · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Interfaces

1 interface between chains.

• A–B · 604 Ų buried · 3 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 27 disulfide, 3 glycan (disulfide, N-glycosylation, O-glycosylation).

Compared structures

• 4CC0 · Notch ligand, Jagged-1, contains an N-terminal C2 domain · the same entry in another collection · chain A against A, TM-score 1.00
• P78504 · AlphaFold monomer V2.0 prediction for protein jagged-1 (P78504) · a predicted model of the same protein · chain B against A, TM-score 0.98

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P78504
• Elsewhere: RCSB PDB 4CC0 · PDBe 4CC0 · UniProt P78504