Research workbench
Crystal structure of the sonic hedgehog-chondroitin-4-sulphate complex
Analyse Crystal structure of the sonic hedgehog-chondroitin-4-sulphate complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4C4M
- Type
- protein
- Length
- 153 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Sonic hedgehog protein
- UniProt
- Q62226
- Ligands
- ASG, BDP, CA, ZN
- Pockets
- 1 · best druggability 0.35
Structure
x-ray diffraction · 1 distinct chain · 26% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Sonic hedgehog protein | protein | 153 | 26% helix, 20% strand | Q62226 |
Ligands and binding sites
- ASG · 2-acetamido-2-deoxy-4-O-sulfo-beta-D-galactopyranose · ligand · 2 copies · chains A
- BDP · beta-D-glucopyranuronic acid · sugar · 2 copies
- CA · Calcium ion · metal · 2 copies · chains A
- ZN · Zinc ion · metal · chains A
- ACT · Acetate ion · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 76 | 0.35 | 0.76 | 18 | empty |
Compared structures
- 4C4M · Crystal structure of the Sonic Hedgehog-chondroitin-4-sulphate complex · the same entry in another collection · chain A against A, TM-score 1.00
- Q62226 · AlphaFold monomer V2.0 prediction for sonic hedgehog protein (Q62226) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q62226
- Elsewhere: RCSB PDB 4C4M · PDBe 4C4M · UniProt Q62226
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