UniProt Q62226
Sonic hedgehog protein (Q62226)
Sonic hedgehog protein (UniProt Q62226): 16 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 27 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q62226
- Protein
- Sonic hedgehog protein
- Experimental structures
- 16
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 27 · 4 records with a druggable one
Structures
17 records of Q62226 in the MolNFT archive: 16 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1VHH | A potential catalytic site within the amino-terminal signalling domain of sonic hedgehog | x-ray diffraction | A | ZN, SO4 | — |
| 1VHH | A potential catalytic site within the amino-terminal signalling domain of sonic hedgehog | x-ray diffraction | A | ZN, SO4 | — |
| 2WFX | Crystal structure of the complex between human hedgehog-interacting protein HIP and Sonic Hedgehog… | x-ray diffraction | A | ZN, CA | 2 (best 0.46) |
| 2WFX | Crystal structure of the complex between human hedgehog- interacting protein hip and sonic hedgehog… | x-ray diffraction | A | ZN, CA | 2 (best 0.46) |
| 2WG4 | Crystal structure of the complex between human hedgehog-interacting protein HIP and sonic hedgehog… | x-ray diffraction | A | ZN | 4 (best 0.39) |
| 2WG4 | Crystal structure of the complex between human hedgehog-interacting protein hip and sonic hedgehog… | x-ray diffraction | A | ZN | 4 (best 0.39) |
| 3D1M | Crystal Structure of Sonic Hedgehog Bound to the third FNIII domain of CDO | x-ray diffraction | A, B | ZN, CA | 2 (best 0.55) |
| 3D1M | Crystal structure of sonic hedgehog bound to the third fniii domain of cdo | x-ray diffraction | A, B | ZN, CA | 2 (best 0.55) |
| 3N1R | Crystal Structure of ShhN | x-ray diffraction | A | ZN, CA | — |
| 3N1R | Crystal structure of shhn | x-ray diffraction | A | ZN, CA | — |
| 4C4M | Crystal structure of the Sonic Hedgehog-chondroitin-4-sulphate complex | x-ray diffraction | A | ASG, ZN, CA | 1 (best 0.35) |
| 4C4M | Crystal structure of the sonic hedgehog-chondroitin-4-sulphate complex | x-ray diffraction | A | ASG, ZN, CA | 1 (best 0.35) |
| 4C4N | Crystal structure of the Sonic Hedgehog-heparin complex | x-ray diffraction | A, B | SGN, IDS, ZN, CA, CL | 1 (best 0.36) |
| 4C4N | Crystal structure of the sonic hedgehog-heparin complex | x-ray diffraction | A, B | SGN, IDS, ZN, CA, CL | 1 (best 0.36) |
| 7RPK | Cryo-EM structure of murine Dispatched in complex with Sonic hedgehog | electron microscopy | H | CA, ZN, SO4 | 5 (best 0.66) |
| 7RPK | Cryo-EM structure of murine dispatched in complex with sonic hedgehog | electron microscopy | H | CA, ZN, SO4 | — |
| Q62226 | AlphaFold monomer V2.0 prediction for sonic hedgehog protein (Q62226) | predicted | A | — | 2 (best 0.66) |
Ligands
- ZN · Zinc ion · in 16 records
- CA · Calcium ion · in 12 records
- SO4 · Sulfate ion · in 4 records
- ASG · 2-acetamido-2-deoxy-4-O-sulfo-beta-D-galactopyranose · in 2 records
- CL · Chloride ion · in 2 records
- IDS · 2-O-sulfo-alpha-L-idopyranuronic acid · in 2 records
- SGN · 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose · in 2 records
Experiment against prediction
- 3N1R chain A against the predicted model Q62226: TM-score 0.99, RMSD 0.33 Å
- 3N1R chain A against the predicted model Q62226: TM-score 0.99, RMSD 0.33 Å
- 4C4N chain A against the predicted model Q62226: TM-score 0.99, RMSD 0.41 Å
- 4C4N chain A against the predicted model Q62226: TM-score 0.99, RMSD 0.41 Å
- 3D1M chain A against the predicted model Q62226: TM-score 0.99, RMSD 0.39 Å
- 3D1M chain A against the predicted model Q62226: TM-score 0.99, RMSD 0.39 Å
- 4C4N chain B against the predicted model Q62226: TM-score 0.99, RMSD 0.41 Å
- 4C4N chain B against the predicted model Q62226: TM-score 0.99, RMSD 0.41 Å
- 3D1M chain B against the predicted model Q62226: TM-score 0.99, RMSD 0.42 Å
- 3D1M chain B against the predicted model Q62226: TM-score 0.99, RMSD 0.42 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.