Research workbench
Crystal structure of M. musculus protein arginine methyltransferase PRMT6 reduced
Analyse Crystal structure of M. musculus protein arginine methyltransferase PRMT6… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4C03
- Type
- protein
- Length
- 665 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein arginine N-methyltransferase 6
- EC
- 2.1.1.-, 2.1.1.125
- UniProt
- Q6NZB1
- Ligands
- SFG
- Pockets
- 6 · best druggability 0.74
Structure
x-ray diffraction · 2 distinct chains · 31% helix, 36% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein arginine N-methyltransferase 6 (EC 2.1.1.-, 2.1.1.125) | protein | 337 | 33% helix, 35% strand | Q6NZB1 |
| B | Protein arginine N-methyltransferase 6 (EC 2.1.1.-, 2.1.1.125) | protein | 328 | 30% helix, 38% strand | Q6NZB1 |
Ligands and binding sites
- SFG · Sinefungin · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 212 | 0.74 | 0.89 | 39 | SFG |
| 2 | 277 | 0.73 | 0.86 | 44 | SFG |
| 3 | 119 | 0.51 | 0.81 | 21 | empty |
| 4 | 110 | 0.51 | 0.81 | 26 | empty |
| 5 | 58 | 0.29 | 0.74 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 1755 Ų buried · 17 hydrogen bonds · protein-protein
Compared structures
- 4C03 · Crystal structure of M. musculus protein arginine methyltransferase PRMT6 reduced · the same entry in another collection · chain A against A, TM-score 1.00
- Q6NZB1 · AlphaFold monomer V2.0 prediction for protein arginine N-methyltransferase 6 (Q6NZB1) · a predicted model of the same protein · chain B against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6NZB1
- Elsewhere: RCSB PDB 4C03 · PDBe 4C03 · UniProt Q6NZB1
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